M Gaster, P Staehr, H Beck-Nielsen, HD Schrøder, A … - Diabetes, 2001 - Am Diabetes Assoc To gain further insight into the mechanisms underlying muscle insulin resistance, the influence
of obesity and type 2 diabetes on GLUT4 immunoreactivity in slow and fast skeletal muscle fibers
was studied. Through a newly developed, very sensitive method using ... Cited by 54 - Related articles - BL Direct - All 4 versions
- ►physiology.org M Gaster, P Poulsen, A Handberg, HD … - American Journal of …, 2000 - Am Physiological Soc GLUT-4 expression in individual fibers of human skeletal muscles in younger and older adults
was studied. Furthermore, the dependency of insulin-stimulated glucose uptake on fiber type
distribution was investigated. Fiber type distribution was determined in cryosections of ... Cited by 36 - Related articles - BL Direct - All 3 versions
J He, S Watkins, DE Kelley - Diabetes, 2001 - Am Diabetes Assoc In obesity and type 2 diabetes, skeletal muscle has been observed to have a reduced oxidative
enzyme activity, increased glycolytic activity, and increased lipid content. These metabolic characteristics
are related to insulin resistance of skeletal muscle and are factors potentially related to ... Cited by 171 - Related articles - BL Direct - All 4 versions
B Nyholm, Z Qu, A Kaal, SB Pedersen, CH Gravholt, JL … - Diabetes, 1997 - Am Diabetes Assoc Insulin resistance is a common feature in first-degree relatives of NIDDM patients. To explore
the mechanism(s) behind this condition in more detail, a percutaneous muscle biopsy (vastus
lateralis) was performed in 25 first-degree relatives of NIDDM patients and 21 control ... Cited by 84 - Related articles - BL Direct - All 4 versions
A Oberbach, Y Bossenz, S Lehmann, J Niebauer, V … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—In the whole muscle, oxidative activity was decreased in patients with type 2
diabetes. The slow oxidative fiber fraction was reduced by 16%, whereas the fast glycolytic fiber
fraction was increased by 49% in skeletal muscle from the diabetic patients. Both ... Cited by 25 - Related articles - BL Direct - All 5 versions
MS Hickey, JO Carey, JL Azevedo, JA … - American Journal of …, 1995 - Am Physiological Soc EUGLYCEMIC CLAMP STUDIES have demonstrated that skeletal muscle accounts for an overwhelming
majority of insulin-mediated glucose disposal in humans (7). Skeletal muscle is composed of
distinct subpopulations of fibers with unique contractile and metabolic character- istics. ... Cited by 104 - Related articles - BL Direct - All 3 versions
P Mårin, B Andersson, M Krotkiewski, P Björntorp - Diabetes Care, 1994 - Am Diabetes Assoc OBJECTIVE--To determine whether muscle fiber composition and capillary density differed between
diabetic and nondiabetic subjects. RESEARCH DESIGN AND METHODS--Muscle fiber composition
and capillary density were determined in biopsies from women and men with non-insulin- ... Cited by 132 - Related articles - BL Direct - All 5 versions
- ►physiology.org MA Selak, BT Storey, I Peterside, RA … - American Journal of …, 2003 - Am Physiological Soc Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes
in later life. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine
growth retardation, in the rat. Early in life, the animals are insulin resistant and by 6 mo of ... Cited by 40 - Related articles - BL Direct - All 4 versions
[CITATION] Immunohistochemical bulk staining of slides using a rack peroxidase-labelled …
