- ►diabetesjournals.org JP Frias, GB Macaraeg, J Ofrecio, JG Yu, JM Olefsky, … - Diabetes, 2001 - Am Diabetes Assoc Elevation of plasma nonesterified fatty acid (NEFA) levels has been shown in various studies
to induce peripheral tissue insulin resistance and impair the suppression of endogenous glucose
production (EGP). These studies have been conducted predominantly in men. We ... Cited by 37 - Related articles - BL Direct - All 5 versions
A Hevener, D Reichart, A Janez, J Olefsky - Diabetes, 2002 - Am Diabetes Assoc It is well described that excessive lipid metabolism can cause insulin resistance in both animals
and humans, and this has been implicated as a causative factor in the development of insulin
resistance and type 2 diabetes in humans. Recently, we have shown that intravenous ... Cited by 32 - Related articles - BL Direct - All 6 versions
CJ Homko, P Cheung, G Boden - Diabetes, 2003 - Am Diabetes Assoc To study effects of sex on free fatty acid (FFA)-induced insulin resistance, we have examined
the effects of acute elevations of plasma FFA levels on insulin-stimulated total body glucose uptake
in nine healthy young women. Euglycemic-hyperinsulinemic (∼500 pmol/l) clamps were ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►endojournals.org G Perseghin, P Scifo, E Pagliato, A Battezzati, S … - Journal of Clinical …, 2001 - Endocrine Soc Plasma free fatty acids and intramyocellular triglycerides (IMCL) content modulate whole body
insulin sensitivity in humans. To test whether the interactions between fatty acid metabolism and
insulin action in nonobese humans are related to gender factors, we studied 15 young, ... Cited by 52 - Related articles - BL Direct - All 6 versions
P Shah, A Vella, A Basu, R Basu, A Adkins, WF … - Diabetes, 2003 - Am Diabetes Assoc The present study sought to determine whether elevated plasma free fatty acids (FFAs) alter
the splanchnic and muscle glucose metabolism in women. To do so, FFAs were increased in
seven women by an 8-h Intralipid/heparin (IL/hep) infusion, and the results were ... Cited by 21 - Related articles - BL Direct - All 5 versions
H Yki-Järvinen - Metabolism: clinical and experimental, 1984 - ncbi.nlm.nih.gov 1: Metabolism. 1984 Nov;33(11):1011-5. Sex and insulin sensitivity. Yki-Järvinen
H. To analyze whether enhanced adiposity in females as compared with males is
associated with a decreased sensitivity to insulin, a group of ... Cited by 63 - Related articles - All 2 versions
- ►endojournals.org E Sivan, CJ Homko, PG Whittaker, EA Reece, X … - Journal of Clinical …, 1998 - Endocrine Soc The purpose of this study was to determine whether elevation of plasma free fatty acids
(FFA) in early pregnancy would cause alterations in insulin-stimulated glucose disposal similar
to those occurring in late gestation. Seven glucose-tolerant women underwent 4-h ... Cited by 36 - Related articles - BL Direct - All 6 versions
- ►eje-online.org B Vistisen, LI Hellgren, T Vadset, C Scheede- … - European Journal of …, 2008 - EFES Objective: In obese subjects, chronically elevated plasma concentrations of non-esterified fatty
acids (NEFAs) exert a marked risk to contract insulin resistance and subsequently type 2
diabetes. When NEFA is acutely increased due to iv infusion of lipid, glucose disposal ... Cited by 8 - Related articles - BL Direct - All 6 versions
- ►endojournals.org YT Kruszynska, DS Worrall, J Ofrecio, JP Frias, … - Journal of Clinical …, 2002 - Endocrine Soc The mechanisms by which elevated plasma nonesterified fatty acid (NEFA) levels induce skeletal
muscle insulin resistance remain unclear. A NEFA-induced defect in the activation of PI3K, which
plays a key role in insulin's stimulation of glucose transport, has been invoked. We sought ... Cited by 80 - Related articles - BL Direct - All 5 versions
PJ Hale, JV Wright, M Nattrass - Metabolism: clinical and experimental, 1985 - ncbi.nlm.nih.gov An incremental intravenous low-dose insulin infusion has been used to examine differences
in insulin sensitivity between normal young men and women. Fasting blood glucose concentration
did not differ significantly at the start of the infusion but women had significantly higher ... Cited by 31 - Related articles - All 2 versions
