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Assessment of hepatic insulin action in obese type 2 diabetic patients

- diabetesjournals.org
P Staehr, O Hother-Nielsen, K Levin, JJ Holst … - Diabetes, 2001 - Am Diabetes Assoc
Defects in hepatic insulin action in type 2 diabetes and its possible underlying
mechanisms were assessed in euglycemic-hyperinsulinemic clamp studies, using
improved tracer methods (constant specific activity technique). Ten obese ...
Cited by 46 - Related articles - BL Direct - All 5 versions

Assessment of Hepatic Insulin Action in Obese Type 2 Diabetic Patients: Results


P Glucose, GS Activity, P FFAs, G … - phx1.medscape.com
Both fasting plasma glucose (9.3 ± 0.6 vs. 5.2 ± 0.1 mmol/l, P < 0.001),
insulin (16 ± 2 vs. 6 ± 1 mU/l, P < 0.01), and C-peptide (1,013 ± 134 vs. 509
± 50 pmol/l, P < 0.01) concentrations were higher in the diabetic patients ...
Related articles

Assessment of Hepatic Insulin Action in Obese Type 2 Diabetic Patients


O Hother-Nielsen, K Levin, H Beck-Nielsen, JJ … - phx1.medscape.com
Defects in hepatic insulin action in type 2 diabetes and its possible underlying
mechanisms were assessed in euglycemic-hyperinsulinemic clamp studies, using
improved tracer methods (constant specific activity technique). Ten obese ...
Related articles - All 4 versions

Assessment of Hepatic Insulin Action in Obese Type 2 Diabetic Patients: Research Design …


OGT Test, EC Studies - phx1.medscape.com
Ten moderately obese type 2 diabetic patients and ten control subjects matched
for age and BMI participated in the studies. Clinical characteristics are given
in the Table 1. None of the diabetic patients had received insulin ...
Related articles

[CITATION] Constant tracer infusion technique for assessment of glucose turnover in vivo: current status


O Hother-Nielsen - Diabetes Research Centre, Department of Medical …
Cited by 6 - Related articles

The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin …

- nih.gov [PDF] 
D Turk, A Alzaid, S Dinneen, KS Nair, R Rizza - Journal of Clinical Investigation, 1995 - pubmedcentral.nih.gov
The mechanism(s) of insulin resistance in non-insulin-de- pendent diabetes
mellitus remains ill defined. The current studies sought to determine whether
non-insulin-dependent diabetes mellitus is associated with (a) a delay in ...
Cited by 35 - Related articles - BL Direct - All 7 versions

Insulin resistance, but normal basal rates of glucose production in patients with newly …


O Hother-Nielsen, H Beck-Nielsen - European Journal of Endocrinology, 1991 - EFES
Fasting hyperglycemia in Type II (non-insulin-dependent) diabetes has been
suggested to be due to hepatic overproduction of glucose and reduced glucose
clearance. We studied 22 patients (10 lean and 12 obese) with newly ...
Cited by 27 - Related articles - All 6 versions

Role of free fatty acids and glucagon in the peripheral effect of insulin on glucose …

- physiology.org
GF Lewis, M Vranic, A Giacca - American Journal of Physiology- Endocrinology And …, 1998 - Am Physiological Soc
We have shown previously that the greater suppression of endogenous glucose
production (GP) with equimolar peripheral vs. portal insulin cannot be detected
or is minimally reversed when the insulin-induced suppression of either ...
Cited by 26 - Related articles - BL Direct - All 4 versions

The direct and indirect effects of insulin on hepatic glucose production in vivo


AD Cherrington, D Edgerton, DK Sindelar - Diabetologia, 1998 - Springer
Glucose production by the liver is controlled on a minute to minute basis by the
plasma insulin and glu- cagon concentrations. Glucagon increases glycogen
breakdown and stimulates the gluconeogenic path- way and insulin inhibits ...
Cited by 79 - Related articles - BL Direct - All 4 versions

Resistance to insulin's acute direct hepatic effect of suppressing steady-state glucose …


GF Lewis, A Carpentier, M Vranic, A Glacca - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc
We and others have shown that insulin acutely suppresses glucose production in
fasting nondiabetic humans and dogs, by both a direct hepatic effect and an
indirect (extrahepatic) effect, and in diabetic dogs by an indirect e ffect ...
Cited by 31 - Related articles - BL Direct - All 4 versions


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