- ►diabetesjournals.org J Kajstura, F Fiordaliso, AM Andreoli, B Li, … - Diabetes, 2001 - Am Diabetes Assoc Stimulation of the local renin-angiotensin system and apoptosis characterize the
diabetic heart. Because IGF-1 reduces angiotensin (Ang) II and apoptosis, we
tested whether streptozotocin-induced diabetic cardiomyopathy was ... Cited by 188 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org A Frustaci, J Kajstura, C Chimenti, I Jakoniuk … - Circulation research, 2000 - Am Heart Assoc Abstract—The renin-angiotensin system is upregulated with diabetes, and this
may contribute to the development of a dilated myopathy. Angiotensin II (Ang II)
locally may lead to oxidative damage, activating cardiac cell death. ... Cited by 337 - Related articles - BL Direct - All 7 versions
F Fiordaliso, B Li, R Latini, EH Sonnenblick, P … - Laboratory Investigation, 2000 - nature.com To determine whether myocyte death and angiotensin II (AT II) formation are
implicated in the development of diabetic cardiomyopathy, rats were injected
with streptozotocin, and apoptosis and necrosis were measured at 3, 10, and ... Cited by 177 - Related articles - BL Direct - All 3 versions
F Fiordaliso, A Leri, D Cesselli, F Limana, B … - Diabetes, 2001 - Am Diabetes Assoc To determine whether enzymatic p53 glycosylation leads to angiotensin II
formation followed by p53 phosphorylation, prolonged activation of the
renin-angiotensin system, and apoptosis, ventricular myocytes were exposed ... Cited by 137 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org L Cai, W Li, G Wang, L Guo, Y Jiang, YJ Kang - Diabetes, 2002 - Am Diabetes Assoc Diabetic cardiomyopathy is related directly to hyperglycemia. Cell death such as
apoptosis plays a critical role in cardiac pathogenesis. Whether hyperglycemia
induces myocardial apoptosis, leading to diabetic cardiomyopathy, remains ... Cited by 170 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org B Li, M Setoguchi, X Wang, AM Andreoli, A … - Circulation research, 1999 - Am Heart Assoc Abstract—Coronary artery narrowing (CAN) induces tissue injury, which may
involve myocyte necrosis and apoptosis. Insulin-like growth factor (IGF)–1 may
counteract cell death, modifying the detrimental effects of myocardial ... Cited by 104 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org A Ceriello, L Quagliaro, MD'Amico, C Di Filippo … - Diabetes, 2002 - Am Diabetes Assoc This study investigated coronary perfusion pressure, nitric oxide (NO) and
superoxide production, nitrotyrosine (NT) formation, and cardiac cell apoptosis
in isolated hearts perfused with high glucose concentration. Coronary ... Cited by 155 - Related articles - BL Direct - All 5 versions
- ►inotekcorp.com [PDF] P Pacher, L Liaudet, FG Soriano, JG Mabley, … - Diabetes, 2002 - Am Diabetes Assoc Patients with diabetes exhibit a high incidence of diabetic cardiomyopathy and
vascular complications, which underlie the development of retinopathy,
nephropathy, and neuropathy and increase the risk of hypertension, stroke, ... Cited by 144 - Related articles - BL Direct - All 9 versions
- ►nih.gov S Pennathur, JD Wagner, C Leeuwenburgh, … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Recent evidence argues strongly that the marked increase in risk for
atherosclerotic heart disease seen in diabetics cannot be explained by a
generalized increase in oxidative stress. Here, we used streptozotocin to ... Cited by 95 - Related articles - BL Direct - All 8 versions
- ►physiology.org FL Norby, LE Wold, J Duan, KK Hintz, J Ren - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc Diabetic cardiomyopathy is characterized by impaired ventricular contraction and
altered function of insulin-like growth factor I (IGF-I), a key factor for
cardiac growth and function. Endogenous IGF-I has been shown to alleviate ... Cited by 54 - Related articles - BL Direct - All 7 versions
