K Ebihara, Y Ogawa, H Masuzaki, M Shintani, F … - Diabetes, 2001 - Am Diabetes Assoc Lipoatrophic diabetes is caused by a deficiency of adipose tissue and is characterized by severe
insulin resistance, hypoleptinemia, and hyperphagia. The A-ZIP/F-1 mouse (A-ZIPTg/+) is a model
of severe lipoatrophic diabetes and is insulin resistant, hypoleptinemic, hyperphagic, and ... Cited by 139 - Related articles - BL Direct - All 5 versions
I Shimomura, RE Hammer, S Ikemoto, MS Brown, JL … - Nature, 1999 - nature.com Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized
by a paucity of adipose (fat) tissue which is evident at birth and is accompanied by a severe resistance
to insulin, leading to hyperinsulinaemia, hyperglycaemia and enlarged fatty liver 1 . We ... Cited by 577 - Related articles - BL Direct - All 6 versions
Y Ogawa, H Masuzaki, K Hosoda, M Aizawa- … - DIABETES-NEW …, 1999 - Am Diabetes Assoc Excess of body fat, or obesity, is a major health problem and confers a higher risk of cardiovascular
and meta- bolic disorders such as diabetes, hypertension, and coronary heart disease. Leptin
is an adipocyte-derived satiety factor that plays an important role in the regu- lation of ... Cited by 145 - Related articles - BL Direct - All 5 versions
C Colombo, JJ Cutson, T Yamauchi, C Vinson, T … - Diabetes, 2002 - Am Diabetes Assoc Severe adipose tissue deficiency (lipoatrophy) causes insulin-resistant diabetes, elevated serum
triglyceride and fatty acid levels, and massive triglyceride deposition in the liver. In lipoatrophic
A-ZIP/F-1 mice, transplantation of normal adipose tissue greatly improved these ... Cited by 68 - Related articles - BL Direct - All 7 versions
- ►nih.gov O Gavrilova, B Marcus-Samuels, D Graham … - Journal of Clinical …, 2000 - Am Soc Clin Investig In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and
hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To
understand the underlying mechanisms, we transplanted adipose tissue into A-ZIP/F-1 ... Cited by 359 - Related articles - BL Direct - All 8 versions
- ►nih.gov [PDF] J Moitra, MM Mason, M Olive, D Krylov, O … - Genes & …, 1998 - genesdev.cshlp.org We have generated a transgenic mouse with no white fat tissue throughout life. These mice express
a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2
enhancer/promoter. This protein prevents the DNA binding of B-ZIP transcription factors of ... Cited by 404 - Related articles - BL Direct - All 7 versions
H Masuzaki, Y Ogawa, M Aizawa-Abe, K Hosoda, J … - Diabetes, 1999 - Am Diabetes Assoc Leptin acts as an adipocyte-derived blood-borne satiety factor that can increase glucose
metabolism. To eluci- date the therapeutic implications of leptin for obesity- associated
diabetes, we crossed transgenic skinny mice overexpressing leptin (Tg/+), which we have ... Cited by 67 - Related articles - BL Direct - All 4 versions
EA Oral, V Simha, E Ruiz, A Andewelt, A … - The New England …, 2002 - nejm.highwire.org Results During treatment with recombinant leptin, the serum leptin level increased from a mean
(±SE) of 1.3±0.3 ng per milliliter to 11.1±2.5 ng per milliliter (0.1±0.02 to 0.9±0.2 nmol per
milliliter). The absolute decrease in the glycosylated hemoglobin value was 1.9 percent ... Cited by 498 - Related articles - BL Direct - All 9 versions
ML Reitman, E Arioglu, O Gavrilova, SI Taylor - Trends in Endocrinology & …, 2000 - Elsevier The lipoatrophy syndromes are a heterogeneous group of syndromes characterized by a paucity
of adipose tissue. Severe lipoatrophy is associated with insulin-resistant diabetes mellitus
(DM). The loss of adipose tissue can have a genetic, immune, or ... Cited by 147 - Related articles - All 6 versions
O Gavrilova, B Marcus-Samuels, LR Leon, C Vinson, … - Nature, 2000 - nature.com Lipoatrophic (lipodystrophic) diabetes is a disorder in which insulin resistance and hyperglycaemia
are associated with a reduced body-fat mass 1 , in contrast to the usual association of diabetes
with obesity. Transgenic mice with differing degrees of fat loss can be used as models for ... Cited by 59 - Related articles - BL Direct - All 6 versions
