- ►diabetesjournals.org H Nakagami, R Morishita, K Yamamoto, S … - Diabetes, 2001 - Am Diabetes Assoc Because high d-glucose significantly stimulates endothelial cell death, we
examined the molecular mechanisms of high d-glucose–induced endothelial
apoptosis. Treatment of human aortic endothelial cells with high d-glucose ... Cited by 62 - Related articles - BL Direct - All 6 versions
H Nakagami, R Morishita, K Yamamoto, Y … - Diabetes, 2002 - Am Diabetes Assoc Injury of endothelial cells has been postulated to be an initial trigger of the
progression of atherosclerosis in patients with diabetes. Previously, we
demonstrated high d-glucose induced endothelial apoptosis through the bax- ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►physiology.org S McGinn, S Saad, P Poronnik, CA Pollock - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc The mitogen-activated protein (MAP) kinases contribute to altered cell growth
and function in a variety of disease states. However, their role in the
endothelial complications of diabetes mellitus remains unclear. Human ... Cited by 27 - Related articles - BL Direct - All 4 versions
S Grethe, MPS Ares, T Andersson, MI Pörn- … - Experimental cell research, 2004 - Elsevier The role of p38 mitogen-activated protein kinase (MAPK) in apoptosis is a matter
of debate. Here, we investigated the involvement of p38 MAPK in endothelial
apoptosis induced by tumor necrosis factor α (TNF). We found that ... Cited by 64 - Related articles - All 5 versions
- ►ahajournals.org FM Ho, SH Liu, CS Liau, PJ Huang, SY Lin- … - Circulation, 2000 - Am Heart Assoc Methods and Results—We elucidated the signaling pathway of high
glucose–induced apoptosis in human umbilical vein endothelial cells (HUVECs).
HUVECs were treated with media containing 5.5, 19, or 33 mmol/L of glucose ... Cited by 140 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org ML Sheu, FM Ho, RS Yang, KF Chao, WW Lin, … - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc Methods and Results— For detection of apoptosis, the morphological Hoechst
staining and Annexin V/propidium iodide staining were used. Glucose upregulated
COX-2 protein expression, which was associated with the induction of ... Cited by 55 - Related articles - All 6 versions
- ►aspetjournals.org ML Sheu, FM Ho, KF Chao, ML Kuo, SH Liu - Molecular pharmacology, 2004 - ASPET Hyperglycemia causes glomerular mesangial cell proliferation and increases
matrix synthesis, contributing to early diabetic glomerulopathy.
Immunohistochemical and functional correlations of renal cyclooxygenase-2 ... Cited by 34 - Related articles - BL Direct - All 4 versions
I Ozaki, E Tani, H Ikemoto, H Kitagawa, H … - Journal of Biological Chemistry, 1999 - ASBMB Apoptosis was induced in human glioma cell lines by exposure to 100 nm
calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced
apoptosis was associated with synchronous down-regulation of Bcl-2 and ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org H Ju, DJ Behm, S Nerurkar, ME Eybye, RE … - Journal of Pharmacology and Experimental …, 2003 - ASPET Numerous mediators, believed to play a role in endothelial dysfunction (eg,
neurohormones, cytokines, hypoxia, and stretch), have been shown to activate p38
mitogen-activated protein kinase (MAPK) in a variety of cell types. The ... Cited by 41 - Related articles - BL Direct - All 4 versions
