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Scholar Results 1 - 10 of about 101 related to Leclerc: Hepatocyte nuclear factor-4α involved in type 1 maturity-onset diabetes of the.... (0.08 sec) 

Hepatocyte nuclear factor-4α involved in type 1 maturity-onset diabetes of the young is a …

- diabetesjournals.org
I Leclerc, C Lenzner, L Gourdon, S Vaulont, A … - Diabetes, 2001 - Am Diabetes Assoc
Mutations in the HNF4α gene are responsible for type 1 maturity-onset diabetes
of the young (MODY1), which is characterized by a defect in insulin secretion.
Hepatocyte nuclear factor (HNF)-4α is a transcription factor that plays a ...
Cited by 83 - Related articles - BL Direct - All 5 versions

AMP-activated protein kinase regulates HNF4 {alpha} transcriptional activity by inhibiting …

- jbc.org
YH Hong, US Varanasi, W Yang, T Leff - Journal of Biological Chemistry, 2003 - ASBMB
AMP-activated protein kinase (AMPK) is the central component of a cellular
signaling system that regulates multiple metabolic enzymes and pathways in
response to reduced intracellular energy levels. The transcription factor ...
Cited by 68 - Related articles - BL Direct - All 4 versions

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I Leclerc, C Lenzner, L Gourdon, S Vaulont, A … - DIABETES, 2001 - Am Diabetes Assoc
Mutations in the HNF4 gene are responsible for type 1 maturity-onset diabetes of
the young (MODY1), which is characterized by a defect in insulin secretion.
Hepato- cyte nuclear factor (HNF)-4 is a transcription factor that plays a ...
Related articles

Regulation of Transcription by AMP-activated Protein Kinase. PHOSPHORYLATION …


W Yang, YH Hong, XQ Shen, C Frankowski, … - Journal of Biological Chemistry, 2001 - ASBMB
AMP-activated protein kinase (AMP-kinase) modulates many metabolic processes in
response to fluctuations in cellular energy status. Although most of its known
targets are metabolic enzymes, it has been proposed that AMP-kinase might ...
Cited by 85 - Related articles - BL Direct - All 3 versions

Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and …

- endojournals.org [PDF] 
A Barthel, D Schmoll, KD Kruger, RA Roth, HG … - Endocrinology, 2002 - Endocrine Soc
0013-7227/02/$ 15.00/0 Printed in USA Endocrinology 143(8):3183-3186 Copyright
© 2002 by The Endocrine Society Regulation of the Forkhead Transcription Factor
FKHR (FOXOla) by Glucose Starvation and AICAR, an Activator of ...
Cited by 46 - Related articles - BL Direct - All 4 versions

AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase …

- jbc.org
M Foretz, D Carling, C Guichard, P Ferre, F … - Journal of Biological Chemistry, 1998 - ASBMB
Although it is now clearly established that a number of genes involved in
glucose and lipid metabolism are up-regulated by high glucose concentrations in
both liver and adipose tissue, the signaling pathway arising from glucose ...
Cited by 149 - Related articles - BL Direct - All 5 versions

Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene …


G da Silva Xavier, I Leclerc, IP Salt, B … - Proceedings of the National Academy of Sciences, 2000 - National Acad Sciences
Elevated glucose concentrations stimulate the transcription of the
pre-proinsulin (PPI), L-type pyruvate kinase (L-PK), and other genes in islet
beta cells. In liver cells, pharmacological activation by 5-amino-4- ...
Cited by 115 - Related articles - BL Direct - All 11 versions

The 5′-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in …


I Leclerc, A Kahn, B Doiron - FEBS letters, 1998 - Elsevier
5-Amino-4-imidazolecarboxamide riboside (AICAR) is known to stimulate rat liver
5′-AMP-activated protein kinase (AMPK). AMPK is the mammalian homologue of
Snf1p in yeast, involved in derepression of glucose-repressed genes. We ...
Cited by 113 - Related articles - All 5 versions

Mechanism for fatty acid" sparing" effect on glucose-induced transcription. Regulation of …

- jbc.org
T Kawaguchi, K Osatomi, H Yamashita, T … - Journal of Biological Chemistry, 2002 - ASBMB
Carbohydrate-responsive element-binding protein (ChREBP) is a new transcription
factor that binds to the carbohydrate-responsive element of the L-type pyruvate
kinase gene (L-PK). The aim of this study was to investigate the mechanism ...
Cited by 138 - Related articles - BL Direct - All 5 versions

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression …

- diabetesjournals.org [PDF] 
PA Lochhead, IP Salt, KS Walker, DG Hardie, … - Diabetes, 2000 - Am Diabetes Assoc
Insulin regulates the rate of expression of many hepatic genes, including PEPCK,
glucose-6-phosphatase (G6Pase), and glucose-6-phosphate dehydrogenase
(G6PDHase). The expression of these genes is also abnormally regulated in ...
Cited by 170 - Related articles - BL Direct - All 6 versions


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