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Scholar Results 1 - 10 of about 101 related to Gerin: Novel arguments in favor of the substrate-transport model of glucose-6-phosphatase. (0.11 sec) 

Novel arguments in favor of the substrate-transport model of glucose-6-phosphatase


I Gerin, G Noël, E Van Schaftingen - Diabetes, 2001 - Am Diabetes Assoc
The purpose of this work was to discriminate between two models for
glucose-6-phosphatase: one in which the enzyme has its catalytic site oriented
toward the lumen of the endoplasmic reticulum, requiring transporters for ...
Cited by 12 - Related articles - BL Direct - All 4 versions

Heterogeneity of glucose transport in rat liver microsomal vesicles


G Bánhegyi, P Marcolongo, A Burchell, A … - Archives of Biochemistry and Biophysics, 1998 - Elsevier
Glucose transport across the membrane of rat liver microsomal vesicles was
studied by a rapid filtration method in three different experimental systems:
(i) inward transport in the presence of extravesicular glucose, (ii) efflux ...
Cited by 15 - Related articles - BL Direct - All 5 versions

An integrated view of the kinetics of glucose and phosphate transport, and of glucose 6- …


W Xie, G Van de Werve, A Berteloot - Journal of Membrane Biology, 2001 - Springer
Abstract. The dynamics of the glucose 6-phosphatase system were investigated in
intact rat liver microsomes using a fast-sampling, rapid-filtration apparatus.
Glu- cose and phosphate transport followed single exponential kinetics, ...
Cited by 8 - Related articles - BL Direct - All 2 versions

Probing into the function of the gene product responsible for glycogen storage disease type …


W Xie, G van de Werve, A Berteloot - FEBS letters, 2001 - Elsevier
This study aimed at directly assessing glucose 6-phosphate (G6P) transport by
intact rat liver microsomes. Tracer uptake from labeled G6P occurred with T 1/2
values that proved insensitive to unlabeled G6P or 100 μM vanadate, and ...
Cited by 4 - Related articles - All 3 versions

Liver microsomal transport of glucose-6-phosphate, glucose, and phosphate in type 1 …

- endojournals.org
P Marcolongo, G Banhegyi, A Benedetti, CJ … - Journal of Clinical Endocrinology & Metabolism, 1998 - Endocrine Soc
The transport of glucose-6-phosphate (G6P), glucose, and orthophosphate into
liver microsomes, isolated from six patients with various subtypes of type 1
glycogen storage disease (GSD), was measured using a light-scattering ...
Cited by 19 - Related articles - BL Direct - All 5 versions

Glucose 6-phosphate transport in fibroblast microsomes from glycogen storage disease type …

- nih.gov [PDF] 
R Leuzzi, R Fulceri, P Marcolongo, G Banhegyi … - Biochemical Journal, 2001 - pubmedcentral.nih.gov
In liver endoplasmic reticulum the intralumenal glucose-6-phos- phatase activity
requires the operation of a glucose 6-phosphate transporter (G6PT1). Mutations
in the gene encoding G6PT1 cause glycogen storage disease type 1b, which is ...
Cited by 16 - Related articles - BL Direct - All 7 versions

Three thiol groups are important for the activity of the liver microsomal glucose-6- …


E Clottes, A Burchell - Journal of Biological Chemistry, 1998 - ASBMB
Liver microsomal glucose-6-phosphatase (Glc-6-Pase) is a multicomponent system
involving both substrate and product carriers and a catalytic subunit. We have
investigated the inhibitory effect of N-ethylmaleimide (NEM), a rather ...
Cited by 19 - Related articles - BL Direct - All 4 versions

Protease inhibitors but not proteases inhibit the glucose-6-phosphatase of native rat liver …


M Speth, HU Schulze - Biochemical and biophysical research communications, 1992 - ncbi.nlm.nih.gov
Controlled proteolytic digestion by trypsin or bacterial proteases limited to
the cytosolic side of the native microsomal membrane is not efficient to inhibit
glucose-6-phosphate hydrolysis. Modification of the microsomes with ...
Cited by 4 - Related articles - All 2 versions

Deficient glucose phosphorylation as a possible common denominator and its relation to …


N Bashan, R Potashnik, A Peist, N Peleg, A … - European Journal of Pediatrics, 1993 - Springer
Abstract. Patients with glycogen storage disease (GSD) lb suffer from recurrent
bacterial infections related to neutropenia and impairment of neutrophil
functions. One of these functions is the oxidative burst activity which is ...
Cited by 10 - Related articles - BL Direct - All 3 versions

Ontogeny of the catalytic subunit and putative glucose-6-phosphate transporter proteins of …


MC Méchin, B Annabi, JP Pegorier, G van de … - Metabolism, 2000 - Elsevier
The catalytic subunit (p36) and putative glucose-6-phosphate (G6P) transporter
(p46) protein levels of the rat glucose-6-phosphatase (G6Pase) system were
studied in relation to G6Pase hydrolytic activity and G6P uptake in liver ...
Cited by 5 - Related articles - BL Direct - All 5 versions


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