- ►diabetesjournals.org K Sjögren, K Wallenius, JL Liu, M Bohlooly-Y, G Pacini, … - Diabetes, 2001 - Am Diabetes Assoc IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate
metabolism. The function of liver-derived IGF-I is still not established, although we previously
demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice ... Cited by 80 - Related articles - BL Direct - All 4 versions
S Yakar, JL Liu, AM Fernandez, Y Wu, AV Schally, J … - Diabetes, 2001 - Am Diabetes Assoc Insulin and insulin-like growth factors (IGFs) mediate a variety of signals involved in mammalian
development and metabolism. To study the metabolic consequences of IGF-I deficiency, we used
the liver IGF-I–deficient (LID) mouse model. The LID mice show a marked reduction ... Cited by 195 - Related articles - BL Direct - All 4 versions
- ►endojournals.org K Wallenius, K Sjogren, XD Peng, S Park, V Wallenius, … - Endocrinology, 2001 - Endocrine Soc We have reported that liver-specific deletion of IGF-I in mice (LI-IGF-I-/-) results in decreased
circulating IGF-I and increased GH levels. In the present study, we determined how elimination
of hepatic IGF-I modifies the hypothalamic-pituitary GH axis to enhance GH secretion. The ... Cited by 48 - Related articles - BL Direct - All 4 versions
AC Moses, SC Young, LA Morrow, M O'brien, DR … - Diabetes, 1996 - Am Diabetes Assoc Insulin resistance is a major factor in the pathophysiology of type II diabetes and a major impediment
to successful therapy. The identification of treatments that specifically target insulin resistance
could improve diabetes management significantly. Since IGFs exert insulin-like actions ... Cited by 138 - Related articles - BL Direct - All 4 versions
PV Carroll, M Umpleby, GS Ward, S Imuere, E … - Diabetes, 1997 - Am Diabetes Assoc IDDM is associated with elevated circulating levels of growth hormone (GH) and reduced
insulin-like growth factor I (IGF-I). GH antagonizes the action of insulin-increasing insulin requirements
in IDDM. The effects of subcutaneously administered rhIGF-I on glycemic control, insulin ... Cited by 52 - Related articles - BL Direct - All 6 versions
PA Crossey, JS Jones, JP Miell - Diabetes, 2000 - Am Diabetes Assoc The insulin/IGF binding protein-1 (IGFBP-1) axis is important in coordinating insulin- and
IGF-mediated regulation of glucose metabolism and glycemia. Dys- regulation of the axis may
play a role in the patho- physiology of disorders of insulin deficiency and resis- tance. We ... Cited by 46 - Related articles - BL Direct - All 3 versions
- ►endojournals.org KA Woods, C Camacho-Hubner, RN Bergman, … - Journal of Clinical …, 2000 - Endocrine Soc We have recently reported a patient with a homozygous partial deletion of the insulin-like growth
factor-I (IGF-I) gene, resulting in IGF-I deficiency, insulin resistance, and short stature. Recombinant
human IGF-I (rhIGF-I) therapy has been shown to improve insulin sensitivity (Si) and ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Tivesten, E Bollano, I Andersson, S Fitzgerald, K … - Endocrinology, 2002 - Endocrine Soc IGF-I has been suggested to be of importance for cardiovascular structure and function, but the
relative role of locally produced and liver-derived endocrine IGF-I remains unclear. Using the
Cre-LoxP recombination system, we have previously created transgenic mice with a liver- ... Cited by 28 - Related articles - BL Direct - All 4 versions
K SJÖGREN, M SHENG, S MOVÉRARE, … - Journal of Bone and …, 2002 - Am Soc Bone Min Res A publication of the American Society for Bone and Mineral Research. Hello.
Sign in to personalize your visit. New user? Register now. ... Cited by 53 - Related articles - BL Direct - All 6 versions
I Ueki, GT Ooi, ML Tremblay, KR Hurst, … - Proceedings of the …, 2000 - National Acad Sciences Insulin-like growth factors (IGFs) I and II are important regulators of cell proliferation and
differentiation. After birth, plasma IGFs, representing mostly liver-derived IGFs, circulate in ternary
complexes of 150 kDa consisting of one molecule each of IGF, IGF-binding protein ... Cited by 70 - Related articles - BL Direct - All 8 versions
