- ►diabetesjournals.org C Tourrel, D Bailbé, MJ Meile, M Kergoat, B Portha - Diabetes, 2001 - Am Diabetes Assoc In neonatal Wistar rats injected with streptozotocin (STZ) at birth (n0-STZ model), a recognized
model of β-cell regeneration, we investigated the capacity of early treatment with glucagon-like
peptide 1 (GLP-1) or exendin-4 to promote β-cell regeneration and thereby improve islet ... Cited by 173 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org C Tourrel, D Bailbe, M Lacorne, MJ Meile, M Kergoat, B … - Diabetes, 2002 - Am Diabetes Assoc In the Goto-Kakizaki (GK) rat, a genetic model of type 2 diabetes, the neonatal β-cell mass deficit
is considered to be the primary defect leading to basal hyperglycemia, which is detectable for
the first time 3 weeks after birth. We investigated in GK females the short- and the ... Cited by 152 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] G Xu, DA Stoffers, JF Habener, S Bonner-Weir - Diabetes, 1999 - Am Diabetes Assoc Diabetes is a disease of increasing prevalence in the general population and of unknown
cause. Diabetes is manifested as hyperglycemia due to a relative defi- ciency of the production
of insulin by the pancreatic -cells. One determinant in the development of dia- betes is an ... Cited by 515 - Related articles - All 4 versions
- ►endojournals.org R Perfetti, J Zhou, ME Doyle, JM Egan - Endocrinology, 2000 - Endocrine Soc Glucose homeostasis in mammals is maintained by insulin secretion from the ß-cells of the islets
of Langerhans. Type 2 diabetes results either from primary ß-cell failure alone and/or a failure
to secrete enough insulin to overcome insulin resistance. Here, we show that continuous ... Cited by 191 - Related articles - BL Direct - All 3 versions
Y Li, T Hansotia, B Yusta, F Ris, PA Halban, DJ … - Journal of Biological …, 2003 - ASBMB Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β cell mass via activation
of β cell proliferation and islet neogenesis. We examined whether GLP-1 receptor signaling modifies
the cellular susceptibility to apoptosis. Mice administered streptozotocin (STZ), an agent ... Cited by 254 - Related articles - BL Direct - All 7 versions
- ►endojournals.org M Szayna, ME Doyle, JA Betkey, HW Holloway, RGS … - Endocrinology, 2000 - Endocrine Soc Exendin-4 is a 39 amino acid peptide produced in the salivary gland of the Gila monster
lizard. It has a 53% amino acid homology to the incretin hormone glucagon-like peptide-1
(GLP-1). Exendin-4 induces insulin release through activation of the GLP-1 receptor but is ... Cited by 195 - Related articles - BL Direct - All 2 versions
J Zhou, X Wang, MA Pineyro, JM Egan - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc In this article, we show that glucagon-like peptide 1 (GLP-1) can induce AR42J cells to differentiate
into insulin, pancreatic polypeptide, and glucagon-positive cells. In their natural state, these
cells, which are derived from a chemically induced pancreatic tumor, possess exocrine ... Cited by 236 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DD De León, S Deng, R Madani, RS Ahima, DJ … - Diabetes, 2003 - Am Diabetes Assoc A reduction in β-cell mass is an important causative factor in type 1 and type 2 diabetes.
Glucagon-like peptide-1 (GLP-1) and the long-acting agonist exendin 4 (Ex-4) expand β-cell
mass by stimulating neogenesis and proliferation. In the partial pancreatectomy (Ppx) ... Cited by 105 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org DA Stoffers, BM Desai, DD DeLeon, RA Simmons - Diabetes, 2003 - Am Diabetes Assoc Uteroplacental insufficiency resulting in fetal growth retardation is a common complication of
pregnancy and a significant cause of perinatal morbidity and mortality. Epidemiological studies
show an increased incidence of type 2 diabetes in humans who were growth retarded at ... Cited by 90 - Related articles - BL Direct - All 4 versions
Q Wang, P Brubaker - Diabetologia, 2002 - Springer Aims/hypothesis. Glucagon-like peptide-1 ameliorates the symptoms of diabetes through stimulation
of insu- lin secretion and enhancement of beta-cell mass. We have therefore investigated the
effects of glucagon- like peptide-1 on the development of diabetes, using db/db mice as a ... Cited by 138 - Related articles - BL Direct - All 4 versions
