A Kowluru, HQ Chen, LM Modrick, C … - Diabetes, 2001 - Am Diabetes Assoc Acetyl-CoA carboxylase (ACC) catalyzes the formation of malonyl-CoA, a precursor
in the biosynthesis of long-chain fatty acids, which have been implicated in
physiological insulin secretion. The catalytic function of ACC is regulated ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] V Gaussin, L Hue, W Stalmans, M Bollen - Biochemical Journal, 1996 - pubmedcentral.nih.gov The activation of hepatic acetyl-CoA carboxylase by Na+-co- transported amino
acids such as glutamine has been attributed mainly to the stimulation of its
dephosphorylation by accumu- lating dicarboxylic acids, eg glutamate. We ... Cited by 29 - Related articles - BL Direct - All 9 versions
- ►bioscirep.cn [PDF] A Kowluru, SA Metz - Bioscience reports, 1998 - Springer Recently, we demonstrated that the 36 kDa catalytic subunit of protein
phosphatase 2A (PP2Ac) undergoes methylation at its C-terminal leucine in normal
rat islets, human islets and isolated b cells; this modification increases ... Cited by 7 - Related articles - BL Direct - All 6 versions
- ►physiology.org R Palanivel, R Veluthakal, A Kowluru - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Previously, we reported that the catalytic subunit of protein phosphatase 2A
(PP2Ac) undergoes carboxylmethylation (CML) at its COOH-terminal leucine, and
that inhibitors of such a posttranslational modification markedly attenuate ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►unige.ch [PDF] C Broca, L Brennan, P Petit, P Newsholme, P … - FEBS letters, 2003 - Elsevier In pancreatic β-cells, glutamate has been proposed to mediate insulin secretion
as a glucose-derived factor, although it is also considered for its sole
catabolic function. Hence, changes in cellular glutamate levels are a ... Cited by 22 - Related articles - All 6 versions
- ►unige.ch [PDF] M Høy, P Maechler, AM Efanov, CB Wollheim … - FEBS letters, 2002 - Elsevier Glutamate has been implicated as an intracellular messenger in the regulation of
insulin secretion in response to glucose. Here we demonstrate by measurements of
cell capacitance in rat pancreatic β-cells that glutamate (1 mM) enhanced ... Cited by 32 - Related articles - All 8 versions
- ►endojournals.org A Sjoholm, M Lehtihet, AM Efanov, SV … - Endocrinology, 2002 - Endocrine Soc In human type 2 diabetes mellitus, loss of glucose-sensitive insulin secretion
is an early pathogenetic event. Glucose is the cardinal physiological stimulator
of insulin secretion from the pancreatic ß-cell, but the mechanisms ... Cited by 16 - Related articles - BL Direct - All 7 versions
- ►jbc.org B Rubi, A del Arco, C Bartley, J Satrustegui, … - Journal of Biological Chemistry, 2004 - ASBMB The NADH shuttle system, which transports reducing equivalents from the cytosol
to the mitochondria, is essential for the coupling of glucose metabolism to
insulin secretion in pancreatic beta cells. Aralar1 and citrin are two ... Cited by 28 - Related articles - All 6 versions
A Danielsson, B Hellman, LA Idahl - Horm Metab Res, 1970 - thieme-connect.com The possibility that conformational changes of glutamate dehydrogenase represent
a way of controlling insulin release was evaluated by measuring the levels of
?-ketoglutarate and glutamate in ?-cells in different states of functional ... Cited by 24 - Related articles - All 2 versions
- ►unige.ch [PDF] B Rubi, H Ishihara, FG Hegardt, CB Wollheim … - Journal of Biological Chemistry, 2001 - ASBMB Mitochondrial metabolism plays a pivotal role in the pancreatic beta cell by
generating signals that couple glucose sensing to insulin secretion. We have
demonstrated previously that mitochondrially derived glutamate participates ... Cited by 50 - Related articles - BL Direct - All 6 versions
