- ►diabetesjournals.org G Boden, B Lebed, M Schatz, C Homko, S Lemieux - Diabetes, 2001 - Am Diabetes Assoc The reason for the 3- to 4-h delay between a rise in plasma free fatty acid (FFA) levels and the
development of insulin resistance remains unknown. In the current study, we have tested the
hypothesis that the delay may be caused by the need for plasma FFAs to first enter ... Cited by 286 - Related articles - BL Direct - All 5 versions
OP Bachmann, DB Dahl, K Brechtel, J Machann, M … - Diabetes, 2001 - Am Diabetes Assoc An increased intramyocellular lipid (IMCL) content, as quantified by 1 H-magnetic resonance
spectroscopy ( 1 H-MRS), is associated with reduced insulin sensitivity. At present, it is unclear
which factors determine IMCL formation and how rapidly IMCL accumulation can be ... Cited by 158 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] G Perseghin, P Scifo, F De Cobelli, E Pagliato, A … - Diabetes, 1999 - Am Diabetes Assoc Determinant of in Vivo Insulin Resistance in Humans ... A 1 H - 1 3 C Nuclear Magnetic Resonance
Spectroscopy ... Assessment in Offspring of Type 2 Diabetic Parents ... Gianluca Perseghin,
Paola Scifo, Francesco De Cobelli, Emanuela Pagliato, Alberto Battezzati, Cinzia ... Cited by 436 - Related articles - BL Direct - All 4 versions
M Krssak, K Falk Petersen, A Dresner, L DiPietro, SM … - Diabetologia, 1999 - Springer Skeletal muscle insulin resistance is a common fea- ture of obesity, dyslipidaemia and arterial
hyperten- sion, and it is an important predisposing factor for Type II (non-insulin-dependent)
diabetes mellitus and premature cardiovascular disease [1]. Evidence has been provided ... Cited by 558 - Related articles - BL Direct - All 6 versions
SI Itani, NB Ruderman, F Schmieder, G Boden - Diabetes, 2002 - Am Diabetes Assoc The possibility that lipid-induced insulin resistance in human muscle is related to alterations
in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers
during euglycemic-hyperinsulinemic clamping in which plasma free fatty acid (FFA) levels ... Cited by 523 - Related articles - BL Direct - All 4 versions
DIW Phillips, S Caddy, V Ilic, BA Fielding, KN Frayn, AC … - Metabolism, 1996 - Elsevier Intracellular triglyceride (TG) is an important energy source for skeletal muscle. However, recent
evidence suggests that if muscle contains abnormally high TG stores its sensitivity to insulin may
be reduced, and this could predispose to type II diabetes. To test this hypothesis, we ... Cited by 250 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BH Goodpaster, J He, S Watkins, DE Kelley - Journal of Clinical …, 2001 - Endocrine Soc We examined the hypothesis that an excess accumulation of intramuscular lipid (IMCL) is associated
with insulin resistance and that this may be mediated by the oxidative capacity of muscle. Nine
sedentary lean (L) and 11 obese (O) subjects, 8 obese subjects with type 2 diabetes ... Cited by 296 - Related articles - BL Direct - All 5 versions
A Virkamäki, E Korsheninnikova, A Seppälä-Lindroos, … - Diabetes, 2001 - Am Diabetes Assoc To examine whether and how intramyocellular lipid (IMCL) content contributes to interindividual
variation in insulin action, we studied 20 healthy men with no family history of type 2
diabetes. IMCL was measured as the resonance of intramyocellular CH 2 protons in lipids/ ... Cited by 148 - Related articles - BL Direct - All 6 versions
S Jacob, J Machann, K Rett, K Brechtel, A … - DIABETES-NEW …, 1999 - Am Diabetes Assoc Insulin resistance plays an important role in the patho- genesis of type 2 diabetes; however, the
multiple mech- anisms causing insulin resistance are not yet fully understood. The aim of this
study was to explore the pos- sible contribution of intramyocellular lipid content in the ... Cited by 361 - Related articles - BL Direct - All 4 versions
DA Pan, S Lillioja, AD Kriketos, MR Milner, LA Baur, C … - Diabetes, 1997 - Am Diabetes Assoc In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate
with reduced skeletal muscle and whole body insulin action. The aim of this study was to test
this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age ... Cited by 619 - Related articles - BL Direct - All 4 versions
