TS Kern, RL Engerman - Diabetes, 2001 - Am Diabetes Assoc Effects of aminoguanidine and aspirin on the development of retinopathy have been examined
in 5-year studies of diabetic dogs. Either agent was administered daily in doses of 20–25 mg
· kg −1 · day −1 . Because severity of hyperglycemia greatly influences development of ... Cited by 165 - Related articles - BL Direct - All 5 versions
- ►iovs.org TS Kern, J Tang, M Mizutani, RA Kowluru, RH … - … ophthalmology & visual …, 2000 - ARVO METHODS. Rats with alloxan-induced diabetes and rats fed a 30% galactose diet (known to
induce diabetic-like retinopathy) were assigned randomly to receive diet with (2.5 g/kg diet) or
without AMG. After 6 to 8 months of diabetes or galactosemia, retinal trypsin digests were ... Cited by 126 - Related articles - BL Direct - All 4 versions
- ►fasebj.org [PDF] AM Joussen, V Poulaki, N Mitsiades, B Kirchhof, K … - The FASEB journal, 2002 - FASEB Page 1. The FASEB Journal express article 10.1096/fj.01-0707fje. Published online
January 30, 2002. Nonsteroidal anti-inflammatory drugs prevent early diabetic
retinopathy via TNF-α suppression Antonia M. Joussen* ,†,fl ... Cited by 213 - Related articles - BL Direct - All 3 versions
- ►physiology.org Y Du, VP Sarthy, TS Kern - American Journal of Physiology- …, 2004 - Am Physiological Soc A nonselective inhibitor of cyclooxygenase (COX; high-dose aspirin) and a relatively selective
inhibitor of inducible nitric oxide synthase (iNOS; aminoguanidine) have been found to inhibit
development of diabetic retinopathy in animals, raising a possibility that NOS and COX ... Cited by 57 - Related articles - BL Direct - All 4 versions
D Boeri, M Maiello, M Lorenzi - Diabetes, 2001 - Am Diabetes Assoc In diabetic retinopathy, capillary nonperfusion and eventual obliteration can lead to retinal ischemia
and sight-threatening neovascularization. The occurrence of retinal microthrombosis in human
diabetes has long been suspected and occasionally observed but never systematically ... Cited by 72 - Related articles - BL Direct - All 4 versions
Y Du, MA Smith, CM Miller, TS Kern - Journal of neurochemistry, 2002 - interscience.wiley.com Aminoguanidine inhibits the development of retinopathy in diabetic animals, but the mechanism
remains unclear. Inasmuch as aminoguanidine is a relatively selective inhibitor of the inducible
isoform of nitric oxide synthase (iNOS), we have investigated the effects of hyperglycemia ... Cited by 84 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org L Zheng, SJ Howell, DA Hatala, K Huang, TS Kern - Diabetes, 2007 - Am Diabetes Assoc It has been previously reported that aspirin inhibited the development of diabetic retinopathy
in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects
on diabetic retinopathy. To further explore this, we compared effects of oral consumption ... Cited by 42 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org A Stitt, TA Gardiner, NL Anderson, P Canning, N … - Diabetes, 2002 - Am Diabetes Assoc We examined the ability of pyridoxamine (PM), an inhibitor of formation of advanced glycation
end products (AGEs) and lipoxidation end products (ALEs), to protect against diabetes-induced
retinal vascular lesions. The effects of PM were compared with the antioxidants vitamin E ( ... Cited by 178 - Related articles - BL Direct - All 6 versions
- ►pnas.org [PDF] HP Hammes, S Martin, K Federlin, K … - Proceedings of the …, 1991 - National Acad Sciences Page 1. Proc. Nadl. Acad. Sci. USA Vol. 88, pp. 11555-11558, December 1991 Medical Sciences
Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy
Wycation/hyperglycemia/microvascular disease/endotheial cells/pericytes) ... Cited by 350 - Related articles - All 8 versions
- ►diabetesjournals.org TS Kern, CM Miller, Y Du, L Zheng, S Mohr, SL Ball, M … - Diabetes, 2007 - Am Diabetes Assoc Pharmacologic treatment of diabetic retinopathy via eyedrops could have advantages but has
not been successful to date. We explored the effect of topical Nepafenac, an anti-inflammatory
drug known to reach the retina when administered via eyedrops, on the development of ... Cited by 35 - Related articles - BL Direct - All 4 versions
