- ►diabetesjournals.org K Maedler, GA Spinas, R Lehmann, P Sergeev … - Diabetes, 2001 - Am Diabetes Assoc In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may
represent one of the essential pro-apoptotic pathways leading to a loss of
pancreatic ß-cells. In the advanced stages of type 2 diabetes, a decline ... Cited by 195 - Related articles - BL Direct - All 5 versions
- ►pnas.org K Maedler, A Fontana, F Ris, P Sergeev, C … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences Type 2 diabetes mellitus results from an inadequate adaptation of the functional
pancreatic β cell mass in the face of insulin resistance. Changes in the
concentration of glucose play an essential role in the regulation of β ... Cited by 96 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org [PDF] MY Donath, DJ Gross, E Cerasi, N Kaiser - Diabetes, 1999 - Am Diabetes Assoc The gerbil Psammomys obesus develops nutrition- dependent diabetes associated
with moderate obesity. The disease is characterized by initial hyperinsulinemia,
progressing to hypoinsulinemia associated with depleted pancreatic insulin ... Cited by 224 - Related articles - BL Direct - All 5 versions
K Maedler, GA Spinas, R Lehmann, P Sergeev … - diabetes, 2001 - Am Diabetes Assoc In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may
represent one of the essential pro- apoptotic pathways leading to a loss of
pancreatic -cells. In the advanced stages of type 2 diabetes, a decline in ... Related articles - All 3 versions
- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to
pancreatic β cells, causing impaired insulin secretion. IL-1β is a
proinflammatory cytokine acting during the autoimmune process of type 1 ... Cited by 324 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org M Federici, M Hribal, L Perego, M Ranalli, Z … - Diabetes, 2001 - Am Diabetes Assoc Type 2 diabetes is characterized by insulin resistance and inadequate insulin
secretion. In the advanced stages of the disease, β-cell dysfunction worsens
and insulin therapy may be necessary to achieve satisfactory metabolic ... Cited by 174 - Related articles - BL Direct - All 5 versions
AC Loweth, GT Williams, RFL James, JHB … - DIABETES-NEW YORK-, 1998 - Am Diabetes Assoc IDDM results from a progressive loss of pancreatic - cells that, in humans, may
be triggered by a combination of genetic and environmental factors. Recently,
atten- tion has been focused on the hypothesis that the loss of -cells is ... Cited by 114 - Related articles - BL Direct - All 4 versions
- ►jbc.org IB Efanova, SV Zaitsev, B Zhivotovsky, M … - Journal of Biological Chemistry, 1998 - ASBMB High concentrations of glucose are considered to be toxic for the pancreatic
-cell. However, the mechanisms underlying -cell dysfunction and resulting cell
death are not fully characterized. In the present study we have ... Cited by 234 - Related articles - BL Direct - All 6 versions
K Maedler, GA Spinas, D Dyntar, W Moritz, N … - Diabetes, 2001 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
unsaturated fatty acids at different glucose concentrations on β-cell ... Cited by 221 - Related articles - BL Direct - All 7 versions
- ►nih.gov K Maedler, P Sergeev, JA Ehses, Z Mathe, D … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences High concentrations of glucose induce β cell production of IL-1β, leading to
impaired β cell function and apoptosis in human pancreatic islets. IL-1
receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1β ... Cited by 82 - Related articles - BL Direct - All 13 versions
