- ►diabetesjournals.org S Assady, G Maor, M Amit, J Itskovitz-Eldor, … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes generally results from autoimmune destruction of pancreatic
islet β-cells, with consequent absolute insulin deficiency and complete
dependence on exogenous insulin treatment. The relative paucity of ... Cited by 671 - Related articles - BL Direct - All 8 versions
B Soria, E Roche, G Berna, T León-Quinto, JA … - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc Embryonic stem (ES) cells display the ability to dif- ferentiate in vitro into a
variety of cell lineages. Using a cell-trapping system, we have obtained an
insulin- secreting cell clone from undifferentiated ES cells. The ... Cited by 695 - Related articles - BL Direct - All 4 versions
- ►colorado.edu [PDF] N Lumelsky, O Blondel, P Laeng, I Velasco, … - Science, 2001 - sciencemag.org Although the source of embryonic stem (ES) cells presents ethical concerns,
their use may lead to many clinical benefits if differentiated cell types can be
derived from them and used to assemble functional organs. In pancreas, ... Cited by 1077 - Related articles - BL Direct - All 18 versions
- ►nih.gov Y Hori, IC Rulifson, BC Tsai, JJ Heit, JD … - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences The use of embryonic stem cells for cell-replacement therapy in diseases like
diabetes mellitus requires methods to control the development of multipotent
cells. We report that treatment of mouse embryonic stem cells with ... Cited by 343 - Related articles - BL Direct - All 10 versions
S Assady, G Maor, M Amit, J Itskovitz-Eldor, … - diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes generally results from autoimmune destruction of pancreatic
islet -cells, with consequent absolute insulin deficiency and complete
dependence on exogenous insulin treatment. The relative paucity of ... Related articles
- ►colorado.edu [PDF] J Rajagopal, WJ Anderson, S Kume, OI … - Science, 2003 - sciencemag.org Despite antibody staining, we did not detect insulin 1 mRNA by reverse
transcription-polymerase chain reaction (RT-PCR) and insulin 2 mRNA detection
was weak. Multiple primers used during all five stages of the protocol (1) ... Cited by 357 - Related articles - All 5 versions
- ►nih.gov P Blyszczuk, J Czyz, G Kania, M Wagner, U … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mouse embryonic stem (ES) cells differentiate into cells of all three primary
germ layers including endodermal cells that produce insulin in vitro. We show
that constitutive expression of Pax4 (Pax4 + ), and to a lesser extent Pdx1 ... Cited by 327 - Related articles - BL Direct - All 11 versions
- ►nih.gov S Bonner-Weir, M Taneja, GC Weir, K … - Proceedings of the National Academy of Sciences of …, 2000 - National Acad Sciences A major obstacle to successful islet transplantation for both type 1 and 2
diabetes is an inadequate supply of insulin-producing tissue. This need for
transplantable human islets has stimulated efforts to expand existing ... Cited by 740 - Related articles - BL Direct - All 10 versions
- ►nih.gov S Levenberg, M Amit, J Itskovitz-Eldor, R … - US Patent App. 10/396,082, 2003 - Google Patents Patent Application Publication Jan. 15,2004 Sheet 1 of 6 US 2004/0009589 Al hES
hEB HUV MEF NT hES hEB HUV MEF NT 0 4 6 8 11 13 18 Day 0 1 234 0 5 10 15 20 0 5
10 15 20 0 5 10 15 20 Days of EB Differentiation FIGURE 1 Cited by 473 - Related articles - BL Direct - All 10 versions
VK Ramiya, M Maraist, KE Arfors, DA Schatz, … - Nature medicine, 2000 - ntbiomol.unibe.ch Islets of Langerhans have a cellular organization ideal for rapid, yet finely
controlled, responses to changes in blood glu- cose levels1–6. During
embryogenesis, islet development seems to be initiated from stem cells ... Cited by 613 - Related articles - View as HTML - BL Direct - All 5 versions
