DE Cummings, JQ Purnell, RS Frayo, K … - Diabetes, 2001 - Am Diabetes Assoc The recently discovered orexigenic peptide ghrelin is produced primarily by the
stomach and circulates in blood at levels that increase during prolonged fasting
in rats. When administered to rodents at supraphysiological doses, ghrelin ... Cited by 1115 - Related articles - BL Direct - All 5 versions
M Tschöp, C Weyer, PA Tataranni, V … - Diabetes, 2001 - Am Diabetes Assoc Ghrelin is a novel endogenous natural ligand for the growth hormone (GH)
secretagogue receptor that has recently been isolated from the rat stomach.
Ghrelin administration stimulates GH secretion but also causes weight gain ... Cited by 891 - Related articles - BL Direct - All 5 versions
M Tschöp, DL Smiley, ML Heiman - Nature, 2000 - nature.com The discovery of the peptide hormone ghrelin, an endogenous ligand for the
growth hormone secretagogue (GHS) receptor 1, 2 , yielded the surprising result
3 that the principal site of ghrelin synthesis is the stomach and not the ... Cited by 1687 - Related articles - BL Direct - All 5 versions
M Nakazato, N Murakami, Y Date, M Kojima, … - Nature, 2001 - nature.com Ghrelin is an acylated peptide that stimulates the release of growth hormone
from the pituitary 1 . Ghrelin-producing neurons are located in the
hypothalamus, whereas ghrelin receptors are expressed in various regions of ... Cited by 1375 - Related articles - BL Direct - All 6 versions
DE Cummings, DS Weigle, RS Frayo, PA Breen … - New England Journal of Medicine, 2002 - content.nejm.org Results Plasma ghrelin levels rose sharply shortly before and fell shortly after
every meal. A diet-induced weight loss of 17 percent of initial body weight was
associated with a 24 percent increase in the area under the curve for the ... Cited by 1018 - Related articles - BL Direct - All 8 versions
- ►endojournals.org T Shiiya, M Nakazato, M Mizuta, Y Date, MS … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Plasma ghrelin concentrations in patients with simple obesity and anorexia
nervosa were lower and higher, respectively, than those of healthy subjects with
normal body weight. Among those with type 2 diabetes mellitus, obese ... Cited by 641 - Related articles - BL Direct - All 5 versions
M Kojima, H Hosoda, Y Date, M Nakazato, H … - Nature, 1999 - nature.com Small synthetic molecules called growth-hormone secretagogues (GHSs) 1, 2, 3
stimulate the release of growth hormone (GH) from the pituitary 4, 5 . They act
through GHS-R, a G-protein-coupled receptor for which the ligand is ... Cited by 3202 - Related articles - BL Direct - All 7 versions
M Tschöp, R Wawarta, RL Riepl, S Friedrich, … - Journal of Endocrinological Investigation, 2001 - ncbi.nlm.nih.gov Ghrelin, an endogenous ligand of the GH secretagogue-receptor, has recently been
shown to stimulate GH secretion and to have orexigenic and adipogenic effects in
rodents, but little is known about its regulation and biological function ... Cited by 299 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Ariyasu, K Takaya, T Tagami, Y Ogawa, K … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated
from rat stomach and is involved in a novel system for regulating GH release.
Although previous studies in rodents suggest that ghrelin is also involved ... Cited by 559 - Related articles - BL Direct - All 4 versions
