K Kelemen, DR Wegmann, JC Hutton - Diabetes, 2001 - Am Diabetes Assoc The protein tyrosine phosphatases (PTPs) IA-2 and phogrin (IA-2β) are major
autoantigens in type 1 diabetes that possess common serological epitopes in
their COOH termini. The epitopes recognized by the T-cells that cause the ... Cited by 15 - Related articles - BL Direct - All 4 versions
P Achenbach, K Kelemen, DR Wegmann, JC … - Journal of Autoimmunity, 2002 - Elsevier Phogrin (IA-2β), a major autoantigen in type 1 diabetes in man is recognized by
peripheral T cells in the nonobese diabetic (NOD) mouse. CD4 + T-cell clones
derived from immunized NOD animals elicit islet destruction in a disease ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] K Kelemen, ML Crawford, RG Gill, JC Hutton … - Diabetes, 1999 - Am Diabetes Assoc The ability of nonobese diabetic (NOD) mice to mount a cellular immune response
to the secretory granule protein tyrosine phosphatase (PTP), phogrin was eval-
uated by immunization of 8- to 12-week-old animals with recombinant phogrin ... Cited by 18 - Related articles - BL Direct - All 4 versions
AL Notkins, J Lu, Q Li, FP VanderVegt, C … - Journal of Autoimmunity, 1996 - Elsevier By subtraction strategy and polymerase chain reaction amplification, two novel
cDNAs, designated IA-2 and IA-2β, were cloned, sequenced and expressed. Both
are transmembrane proteins belonging to the protein tyrosine phosphatase ... Cited by 17 - Related articles - All 4 versions
K Kimura, T Kawamura, S Kadotani, H Inada, … - Diabetes research and clinical practice, 2001 - Elsevier Cytotoxic T lymphocytes (CTL) against pancreatic β-cells probably play a major
role in the etiology of type 1 diabetes mellitus (DM). CTLs recognize a complex
formed between MHC class I and antigenic peptides fragments derived from ... Cited by 14 - Related articles - All 6 versions
- ►pasteur.ac.ir [PDF] L Bowie, J Tite, A Cooke - Journal of immunological methods, 1999 - Elsevier The non-obese diabetic (NOD) mouse develops insulin dependent diabetes mellitus
(IDDM) spontaneously with a higher incidence in females than in males. There are
many similarities to the human disease, making it an ideal model. Our group ... Cited by 10 - Related articles - All 6 versions
N Videbæk, S Harach, J Phillips, P … - Journal of Autoimmunity, 2003 - Elsevier T cells play a central role in the development of diabetes both in man and in
the non-obese diabetic (NOD) mouse. Both the CD4 + and CD8 + subsets of T cells
are required for the normal development of IDDM in NOD mice. Islet reactive ... Cited by 11 - Related articles - BL Direct - All 3 versions
YC Kudva, YJ Deng, R Govindarajan, RS … - Human Immunology, 2001 - Elsevier Type 1 diabetes mellitus is strongly associated with HLA-DQ8 in humans and IA g7
in the NOD mouse. The disease is characterized by loss of tolerance to
auto-antigens such as GAD, insulin, and the protein tyrosine ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] CJ Hawkes, NC Schloot, J Marks, SJ Willemen … - Diabetes, 2000 - Am Diabetes Assoc Type 1 diabetes is the result of destruction of the insulin-secreting -cells of
the pancreas by a process in which T-cells play a central role. A tyrosine
phospha- tase-like protein, IA-2, is a major target for autoanti- bodies ... Cited by 63 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org P Halbout, JP Briand, C Becourt, S Muller, C … - The Journal of Immunology, 2002 - Am Assoc Immnol Immunization against insulin, insulin B chain, or B chain peptide B 9–23
(preproinsulin peptide II 33–47 ) prevents diabetes in the nonobese diabetic
(NOD) mouse. Whether or not peptide II 33–47 is the only proinsulin ... Cited by 27 - Related articles - BL Direct - All 4 versions
