- ►diabetesjournals.org MI Darville, DL Eizirik - Diabetes, 2001 - Am Diabetes Assoc Fas-mediated cell death may play a role in the autoimmune destruction of
pancreatic β-cells in type 1 diabetes. β-Cells do not express Fas under
physiological conditions, but Fas mRNA and protein are induced in cytokine- ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MI Darville, YS Ho, DL Eizirik - Endocrinology, 2000 - Endocrine Soc Reactive oxygen species play an important role in the cytotoxic effect of
inflammatory cytokines on pancreatic ß-cells in type 1 diabetes mellitus. The
antioxidant enzyme manganese superoxide dismutase (MnSOD) is part of the ... Cited by 62 - Related articles - BL Direct - All 2 versions
D Pavlovic, MC Chen, CA Gysemans, C … - Eur. Cytokine Netw, 1999 - john-libbey-eurotext.fr Summary : Combinations of cytokines, including interleukin-1beta (IL-1beta) and
interferon-gamma (IFN-gamma), induce nitric oxide (NO) production and cell death
in pancreatic islet cells. We have previously shown that these events are ... Cited by 44 - Related articles - BL Direct - All 6 versions
N Giannoukakis, WA Rudert, M Trucco, PD … - Journal of Biological Chemistry, 2000 - ASBMB Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell
function and promotes Fas-triggered apoptosis. IL-1β is thought to act early in
the initiation of the autoimmune destruction of pancreatic β cells in type ... Cited by 127 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] D Liu, D Pavlovic, MC Chen, M Flodström, S … - Diabetes, 2000 - Am Diabetes Assoc Prolonged exposure of rodent -cells to combinations of cytokines induces the
inducible form of nitric oxide synthase (iNOS) expression and Fas expression,
nitric oxide (NO) production, and cell death. It also induces the ... Cited by 165 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Heimberg, Y Heremans, C Jobin, R Leemans, … - Diabetes, 2001 - Am Diabetes Assoc Cytokine-induced β-cell death is an important event in the pathogenesis of type
1 diabetes. The transcription factor nuclear factor-κB (NF-κB) is activated by
interleukin-1β (IL-1β), and its activity promotes the expression of ... Cited by 129 - Related articles - BL Direct - All 4 versions
MI Darville, DL Eizirik - Diabetologia, 1998 - Springer Type I (insulin-dependent) diabetes mellitus results from a selective
destruction of the pancreatic insu- lin-producing beta cells. Cytokines,
especially inter- leukin-1b (IL-1b), could play an important role in im- ... Cited by 113 - Related articles - BL Direct - All 3 versions
H Heimberg, Y Heremans, C Jobin, R Leemans, … - Diabetes, 2001 - Am Diabetes Assoc Page 1. Inhibition of Cytokine-Induced NF- B Activation by Adenovirus-Mediated
Expression of a NF- B Super-Repressor Prevents -Cell Apoptosis ... Cited by 50 - Related articles
M Moriwaki, N Itoh, J Miyagawa, K Yamamoto … - Diabetologia, 1999 - Springer Type I (insulin-dependent) diabetes mellitus is thought to be a cell-mediated
autoimmune disease characterized by the selective destruction of pancreat- ic
betacells [1,2].Severallinesof evidencehaveestab- lished a critical role ... Cited by 100 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org AK Cardozo, M Kruhøffer, R Leeman, T Ørntoft, … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from the selective
destruction of insulin-producing β-cells. Cytokines may contribute to
pancreatic β-cell death in type 1 diabetes. β-cell exposure to ... Cited by 145 - Related articles - BL Direct - All 4 versions
