- ►diabetesjournals.org M Cnop, JC Hannaert, A Hoorens, DL Eizirik, … - Diabetes, 2001 - Am Diabetes Assoc Studies in Zucker diabetic fatty rats have led to the concept that chronically
elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden
pancreatic β-cells as a result of the formation of ceramides, which induce ... Cited by 216 - Related articles - BL Direct - All 9 versions
K Maedler, GA Spinas, D Dyntar, W Moritz, N … - Diabetes, 2001 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
unsaturated fatty acids at different glucose concentrations on β-cell ... Cited by 221 - Related articles - BL Direct - All 7 versions
K Maedler, J Oberholzer, P Bucher, GA … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
monounsaturated fatty acids at different glucose concentrations on human ... Cited by 149 - Related articles - BL Direct - All 5 versions
- ►endojournals.org I Maestre, J Jordan, S Calvo, JA Reig, V Cena … - Endocrinology, 2003 - Endocrine Soc The potential toxic effects of high extracellular concentrations of fatty acids
were tested in ß(INS-1)-cells cultured in the absence of serum, a condition
known to alter cell survival in various systems. This may in part mimic the ... Cited by 82 - Related articles - BL Direct - All 8 versions
- ►pnas.org LL Listenberger, X Han, SE Lewis, S Cases, … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Excess lipid accumulation in non-adipose tissues is associated with insulin
resistance, pancreatic β-cell apoptosis and heart failure. Here, we demonstrate
in cultured cells that the relative toxicity of two common dietary long ... Cited by 310 - Related articles - BL Direct - All 10 versions
R Lupi, F Dotta, L Marselli, S Del Guerra, M … - Diabetes, 2002 - Am Diabetes Assoc In an effort to better understand the phenomenon of lipotoxicity in human
β-cells, we evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l
free fatty acid (FFA) (2:1 oleate to palmitate) on the function and ... Cited by 268 - Related articles - BL Direct - All 7 versions
- ►nih.gov M Shimabukuro, YT Zhou, M Levi, RH Unger - Proceedings of the National Academy of Sciences of …, 1998 - National Acad Sciences Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early β cell
compensation for insulin resistance (4-fold β cell hyperplasia) followed by
decompensation (>50% loss of β cells). In prediabetic and diabetic ZDF ... Cited by 642 - Related articles - BL Direct - All 13 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty
acids (FFAs) together with hyperglycemia are synergistic in causing islet
ß-cell damage because high glucose inhibits fat oxidation and consequently ... Cited by 173 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org I Briaud, JS Harmon, CL Kelpe, VBG Segu, V … - Diabetes, 2001 - Am Diabetes Assoc Prolonged exposure of isolated islets to supraphysiologic concentrations of
palmitate decreases insulin gene expression in the presence of elevated glucose
levels. This study was designed to determine whether or not this phenomenon ... Cited by 139 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] YP Zhou, VE Grill - Journal of Clinical Investigation, 1994 - pubmedcentral.nih.gov We tested effects of long-term exposure of pancreatic islets to free fatty acids
(FFA) in vitro on B cell function. Islets isolated from male Sprague-Dawley rats
were exposed to palmitate (0.125 or 0.25 mM), oleate (0.125 mM), or ... Cited by 385 - Related articles - BL Direct - All 9 versions
