CB Juhl, N Pørksen, SM Pincus, ÅP Hansen, JD … - Diabetes, 2001 - Am Diabetes Assoc The high-frequency oscillatory pattern of insulin release is disturbed in type 2 diabetes. Although
sulfonylurea drugs are widely used for the treatment of this disease, their effect on insulin release
patterns is not well established. The aim of the present study was to assess the impact of ... Cited by 20 - Related articles - BL Direct - All 4 versions
M Hollingdal, J Sturis, MA Gall, P Damsbo, S … - Diabet Med, 2005 - interscience.wiley.com Methods We examined 10 patients with Type 2 diabetes in a double-blind
placebo-controlled, cross-over design. The participants were treated for 6 weeks with either repaglinide
[2–9 mg/day (average 5.9 mg)] or placebo in random order. At the end of each treatment ... Cited by 11 - Related articles - BL Direct - All 6 versions
CB Juhl, N Porksen, M Hollingdal, J Sturis, S … - Diabetes care, 2000 - Am Diabetes Assoc I nsulin release is characterized by a coordi- nated pulsatile mode of secretion with a periodicity
of 5–15 min/pulse, leading to oscillations in peripheral insulin concentra- tions (1,2). The impact
of pulsatile insulin delivery on metabolism is well established in vivo and in vitro (3–6). ... Cited by 19 - Related articles - BL Direct - All 7 versions
DR Matthews, O Boland - Metabolism, 1997 - Elsevier Sulfonylureas stimulate insulin secretion as their predominant contribution toward decreasing
blood glucose in diabetic patients. We studied eight gliclazide-treated, non—insulin-dependent
diabetic patients on two occasions with a protocol of basal observation for 30 minutes, a ... Cited by 6 - Related articles - BL Direct - All 5 versions
- ►physiology.org N Porksen, C Juhl, M Hollingdal, SM … - American Journal of …, 2000 - Am Physiological Soc Insulin is largely secreted as serial secretory bursts superimposed on basal release, insulin secretion
is regulated through changes of pulse mass and frequency, and the insulin release pattern affects
insulin action. Coordinate insulin release is preserved in the isolated perfused pancreas, ... Cited by 21 - Related articles - BL Direct - All 3 versions
CB Juhl, O Schmitz, S Pincus, JJ Holst, J Veldhuis, N … - Diabetologia, 2000 - Springer Type II (non-insulin-dependent) diabetes mellitus is among a vast number of abnormalities characterised
by disturbed beta-cell function. This includes defects in first-phase and second-phase insulin
secretion as ... Short-term treatment with GLP-1 increases pulsatile insulin Cited by 18 - Related articles - BL Direct - All 4 versions
M Hollingdal, CB Juhl, SM Pincus, J Sturis, … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Insulin is released in high-frequency pulsatile bursts at intervals of 6–13 min. Intrapancreatic
mechanisms are assumed to coordinate pulsatile insulin release, but small oscillations in plasma
glucose concentrations may contribute further. To gain additional insight into -cell (patho) ... Cited by 33 - Related articles - BL Direct - All 5 versions
CS Mao, N Berman, K Roberts, E Ipp - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc Regular high-frequency oscillations of insulin secre- tion are characteristic of normal -cell
function. These oscillations are easily entrainable to an exogenous rhythm by small changes
in glucose concentration in vitro. We tested whether high-frequency insulin oscil- lations ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►biologists.org N Kumar, CS Dey - Journal of Experimental Biology, 2002 - jeb.biologists.org Sulfonylurea drugs are used in the treatment of type 2 diabetes. The mechanism of action of
sulfonylureas is to release insulin from pancreatic cells and they have been proposed to act on
insulin-sensitive tissues to enhance glucose uptake. The goal of the present study was to ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JM Lin, ME Fabregat, R Gomis, P Bergsten - Diabetes, 2002 - Am Diabetes Assoc Plasma insulin in healthy subjects shows regular oscillations, which are important for the hypoglycemic
action of the hormone. In individuals with type 2 diabetes, these regular variations are
altered, which has been implicated in the development of insulin resistance and ... Cited by 24 - Related articles - BL Direct - All 5 versions
