- ►diabetesjournals.org G Leibowitz, S Ferber, Å Apelqvist, H Edlund, DJ Gross, … - Diabetes, 2001 - Am Diabetes Assoc The homeodomain transcription factor IPF1/PDX1 is required in ß-cells for efficient expression
of insulin, glucose transporter 2, and prohormone convertases 1/3 and 2. Psammomys
obesus, a model of diet-responsive type 2 diabetes, shows markedly depleted insulin ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] R Nesher, DJ Gross, MY Donath, E Cerasi, N Kaiser - Diabetes, 1999 - Am Diabetes Assoc The gerbil Psammomys obesus develops nutrition- dependent diabetes. We studied the interaction
between diet and diabetic predisposition for - cell function. A 4-day high-energy (HE) diet induced
a 3-, 4-, and 1.5-fold increase in serum glucose, insulin, and triglycerides, respectively, in ... Cited by 23 - Related articles - BL Direct - All 4 versions
DJ Gross, G Leibowitz, E Cerasi, N Kaiser - Endocrinology, 1996 - Endocrine Soc Page 1. 0013.7227/96/$03 00/o Vol. 137, No. 12 Endocrmology Printed ,n USA CopyrIght 0
1996 by The Endocrine Soclet> Increased Susceptibility of Islets from Diabetes-Prone
Psammomys obesus to the Deleterious Effects of Chronic Glucose Exposure* ... Cited by 23 - Related articles - BL Direct - All 4 versions
M Gadot, G Leibowitz, E Shafrir, E Cerasi, DJ Gross, N … - Endocrinology, 1994 - Endocrine Soc Page 1. 0013.7227/94/1352-0610$03.00/0 Endocrinology Copyright 0 1994 by The
Endocrine Society Vol. 135, No. 2 Printed in USA Hyperproinsulinemia and Insulin
Deficiency in the Diabetic Psammomys obesus* M. GADOT ... Cited by 40 - Related articles - BL Direct - All 3 versions
- ►endojournals.org G Leibowitz, G Uckaya, AI Oprescu, E Cerasi, DJ Gross … - Endocrinology, 2002 - Endocrine Soc UNDER PHYSIOLOGICAL CONDITIONS, the secretion and biosynthesis of insulin are
coordinated. Indeed, stimulation of insulin release is associated with a rapid and sustained increase
of proinsulin biosynthesis thus preventing the depletion of pancreatic insulin stores (1). ... Cited by 21 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org [PDF] WM Macfarlane, RM Shepherd, KE Cosgrove, RF … - Diabetes, 2000 - Am Diabetes Assoc Glucose regulates insulin production in pancreatic -cells in the long term by stimulating insulin
gene transcription. These effects are partially mediated through the activity of a homeodomain
transcription factor, PDX-1, which binds to four sites within the human insulin gene ... Cited by 45 - Related articles - BL Direct - All 4 versions
M Brissova, M Shiota, WE Nicholson, M Gannon, … - Journal of Biological …, 2002 - ASBMB Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity
for PDX-1 mutations has been recently noted in some individuals with maturity-onset diabetes
of the young (MODY) and in some individuals with type 2 diabetes. To determine how ... Cited by 121 - Related articles - BL Direct - All 8 versions
M Karaca, C Magnan, C Kargar - Diabetes and Metabolism, 2009 - Elsevier In the adult, the pancreatic β-cell mass adapts insulin secretion to meet long-term changes in
insulin demand and, in particular, in the presence of insulinresistance that is either
physiological, such as pregnancy, or pathophysiological, such as obesity. The failure of β ... Cited by 3 - Related articles - All 2 versions
[CITATION] In't Veld P, Mahler T, Schuit F, Van De Winkel M, et al.(1992) Differences in glucose …
A Jörns, M Tiedge, E Ziv, E Shafrir, S Lenzen - Virchows Archiv, 2002 - Springer Abstract The Psammomys obesus (sand rat) is a well- established model of nutritionally induced
non-insulin- dependent type-2 diabetes. When fed a high-energy (HE) diet, the diabetes-prone
animals develop hyperin- sulinaemia and hyperglycaemia. Within 1 week, all ani- mals ... Cited by 33 - Related articles - BL Direct - All 4 versions
