- ►diabetesjournals.org ED Slosberg, UJ Desai, B Fanelli, I St Denny, S … - Diabetes, 2001 - Am Diabetes Assoc The enzyme glucokinase (GK) plays a central role in glucose homeostasis. Hepatic GK activity
is acutely controlled by the action of the GK regulatory protein (GKRP). In vitro evidence suggests
that GKRP reversibly binds to GK and inhibits its activity; however, less is known about ... Cited by 27 - Related articles - BL Direct - All 7 versions
B Koster, M Fenger, P Poulsen, A Vaag, J … - Diabetic …, 2005 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 4 - Related articles - BL Direct - All 4 versions
T Sparsø, G Andersen, T Nielsen, KS Burgdorf, AP … - Diabetologia, 2008 - Springer Page 1. ARTICLE The GCKR rs780094 polymorphism is associated with elevated fasting
serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of
type 2 diabetes T. Sparsø & G. Andersen & T. Nielsen & KS Burgdorf & ... Cited by 22 - Related articles - BL Direct - All 4 versions
RM O'Doherty, DL Lehman, S Telemaque-Potts, CB … - Diabetes, 1999 - Am Diabetes Assoc The balance between hepatic glucose uptake and pro- duction is perturbed in both major forms
of diabetes. It has been suggested that pharmacologic or genetic methods for enhancing glucokinase
(GK) enzymatic activity in liver might be a means of increasing glucose disposal and ... Cited by 100 - Related articles - BL Direct - All 4 versions
J Grimsby, JW Coffey, MT Dvorozniak, J Magram, G … - Journal of Biological …, 2000 - ASBMB The glucokinase regulatory protein (GKRP) inhibits glucokinase competitively with respect to
glucose by forming a protein-protein complex with this enzyme. The physiological role of GKRP
in controlling hepatic glucokinase activity was addressed using gene targeting to disrupt ... Cited by 59 - Related articles - BL Direct - All 4 versions
M Vaxillaire, C Cavalcanti-Proença, A Dechaume, J … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal
in the liver, where its activity is competitively modulated, with respect to glucose, by binding to
glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate. Genome- ... Cited by 9 - Related articles - All 4 versions
M Orho-Melander, O Melander, C Guiducci, P Perez- … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We performed association studies in 12 independent
cohorts comprising >45,000 individuals representing several ancestral groups (whites from Northern
and Southern Europe, whites from the US, African Americans from the US, Hispanics of ... Cited by 21 - Related articles - All 11 versions
- ►pnas.org D Farrelly, KS Brown, A Tieman, J Ren, … - Proceedings of the …, 1999 - National Acad Sciences The importance of glucokinase (GK; EC 2.7.1.12) in glucose homeostasis has been demonstrated
by the association of GK mutations with diabetes mellitus in humans and by alterations in glucose
metabolism in transgenic and gene knockout mice. Liver GK activity in humans and ... Cited by 60 - Related articles - All 9 versions
- ►physiology.org C Wu, DA Okar, CB Newgard, AJ … - American Journal of …, 2002 - Am Physiological Soc Hepatic glucose production is increased as a metabolic consequence of insulin resistance in
type 2 diabetes. Because fructose 2,6-bisphosphate is an important regulator of hepatic glucose
production, we used adenovirus-mediated enzyme overexpression to increase hepatic ... Cited by 26 - Related articles - BL Direct - All 3 versions
- ►cnfindpark.cn P Perez-Martinez, D Corella, J Shen, DK … - American Journal of …, 2009 - ajcn.cnfindpark.cn 1 From the Nutrition and Genomics Laboratory (PP-M, DC, JS, C-QL, LDP, and JMO) and the
Dietary Assessment and Epidemiology Research Program (KLT), Jean Mayer–US Department
of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA; ... Cited by 3 - Related articles - All 15 versions
