H Wang, J Rissanen, R Miettinen, P … - Diabetes, 2001 - Am Diabetes Assoc We investigated the significance of the variants of the IRS-2 gene in patients
with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by
single-strand conformation polymorphism analysis in 40 Chinese and 40 ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►endojournals.org R D'Alfonso, MA Marini, L Frittitta, R Sorge, S … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc We investigated the significance of Gly1057Asp and Leu647Val insulin receptor
substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186
glucose-tolerant subjects and 240 subjects with type 2 diabetes from the ... Cited by 15 - Related articles - BL Direct - All 5 versions
- ►endojournals.org A Fritsche, A Madaus, W Renn, O Tschritter, A … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc Disruption of the insulin receptor substrate-2 was shown to cause type 2
diabetes in mice. This could be largely attributed to abnormal ß-cell
development. In humans, a prevalent polymorphism in insulin receptor ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►whitelabs.org [PDF] K Almind, SK Frederiksen, D Bernal, T … - Diabetologia, 1999 - Springer The importance of the insulin receptor substrate-2 (IRS-2) has recently been
investigated in mice in which the homozygous deficiency of IRS-2 causes a Type
II (non-insulin-dependent) diabetes-like pheno- type due to both insulin ... Cited by 47 - Related articles - BL Direct - All 5 versions
N Stefan, P Kovacs, M Stumvoll, RL Hanson, A … - Diabetes, 2003 - Am Diabetes Assoc Insulin receptor substrate (IRS)-2 plays an important role in insulin signaling
and its disruption results in diabetes in mice. In humans, the IRS-2 Gly1057Asp
substitution was associated with lower risk of type 2 diabetes in lean ... Cited by 37 - Related articles - BL Direct - All 4 versions
D Bernal, K Almind, L Yenush, M Ayoub, Y … - DIABETES-NEW YORK-, 1998 - Am Diabetes Assoc Type 2 diabetes is a complex disease characterized by insulin resistance in
target tissues and a reduced capacity to produce compensatory levels of insulin
in pancreatic -cells (1). Not surpris- ingly, a single molecular defect ... Cited by 67 - Related articles - BL Direct - All 7 versions
K Okazawa, Y Yoshimasa, Y Miyamoto, A … - Diabetes research and clinical practice, 2005 - Elsevier A commonly occurring nucleotide polymorphism of the insulin-receptor substrate 2
(IRS-2) gene at amino acid 1057 from Glycine to Asparaginic acid (G1057D) was
recently shown to be a determinant of insulin sensitivity in both glucose- ... Cited by 7 - Related articles - All 10 versions
- ►oxfordjournals.org S Mammarella, F Romano, A Di Valerio, B … - Human Molecular Genetics, 2000 - Oxford Univ Press The insulin receptor substrate-2 (IRS-2) is a major insulin signalling molecule.
IRS-2 inactivation in mice induces a form of diabetes characterized by
peripheral insulin resistance and reduced beta cell mass. We tested the ... Cited by 61 - Related articles - BL Direct - All 4 versions
K Almind, SK Frederiksen, MG Ahlgren, S … - Diabetologia, 1998 - Springer Recent studies have identified a family of insulin re- ceptor substrates
(IRS1-4) [1, 2, 3]. The insulin recep- tor substrates are cytoplasmic docking
proteins which undergo tyrosine phosphorylation upon stimulation with ... Cited by 18 - Related articles - BL Direct - All 3 versions
[CITATION] Polymorphisms of the IRS-2 in patients with type 2 diabetes
R D'Alfonso, MA Marini, L Frittita, R Sorge, S … - J Clin Endocrinol Metab, 2003 Cited by 2 - Related articles
