L Frittitta, T Ercolino, M Bozzali, A Argiolas, S Graci, MG … - Diabetes, 2001 - Am Diabetes Assoc Glycoprotein PC-1 inhibits insulin signaling and, when overexpressed, plays a role in human
insulin resistance. Mechanisms of PC-1 overexpression are unknown. We have identified a haplotype
in the 3′-untranslated region of the PC-1 gene that may modulate PC-1 expression and ... Cited by 46 - Related articles - BL Direct - All 4 versions
HF Gu, P Almgren, E Lindholm, L Frittttta, A … - DIABETES-NEW …, 2000 - Am Diabetes Assoc We studied whether there is an association between the single nucleotide polymorphism
c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syn- drome in
case-control and intrafamily association studies in 922 subjects from Finland and ... Cited by 93 - Related articles - BL Direct - All 4 versions
LH Canani, DPK Ng, A Smiles, JJ Rogus, JH Warram, … - Diabetes, 2002 - Am Diabetes Assoc A polymorphism in the ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene
(ENPP1) (previously known as PC-1), resulting in an amino acid change from lysine to glutamine
at codon 121 (K121Q), is associated with insulin resistance. A small follow-up study of ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] SK Rasmussen, SA Urhammer, A Pizzuti, SM Echwald, … - Diabetes, 2000 - Am Diabetes Assoc The human plasma-cell membrane differentiation anti- gen-1 (PC-1) has been shown to inhibit
insulin receptor tyrosine kinase activity. Recently, a K121Q polymor- phism in the human
PC-1 gene was found in a Sicilian population and was shown to be strongly associated ... Cited by 67 - Related articles - BL Direct - All 4 versions
BV Costanzo, V Trischitta, R Di Paola, D Spampinato, A … - Diabetes, 2001 - Am Diabetes Assoc When overexpressed, the membrane glycoprotein PC-1 may play a role in human insulin resistance
through the inhibition of insulin receptor (IR) autophosphorylation. A PC-1 variant (K 121 Q, with
lysine 121 replaced by glutamine) is also associated with whole-body insulin resistance ... Cited by 76 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] BA Maddux, ID Goldfine - Diabetes, 2000 - Am Diabetes Assoc Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyrosine kinase activity
and sub- sequent cellular signaling. PC-1 content is elevated in fibroblasts, muscle, and adipose
tissue from insulin- resistant subjects, and its elevation correlates with in vivo insulin ... Cited by 108 - Related articles - BL Direct - All 7 versions
A Pizzuti, L Frittitta, A Argiolas, R Baratta, ID … - DIABETES-NEW …, 1999 - Am Diabetes Assoc The genes responsible for insulin resistance are poorly defined. Plasma cell differentiation antigen
(PC-1) gly- coprotein inhibits insulin receptor signaling and is associated with insulin
resistance. We describe here a novel polymorphism in exon 4 of the PC-1 gene (K121Q) ... Cited by 147 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Frittitta, S Camastra, R Baratta, BV Costanzo, … - Journal of Clinical …, 1999 - Endocrine Soc A soluble PC-1, with mol wt and enzymatic activity similar to those of tissue PC-1, was measurable
in human plasma by a specific enzyme-linked immunosorbent assay and was inversely correlated
to skeletal muscle PC-1 content (r = -0.5; P < 0.01). The plasma PC-1 concentration was ... Cited by 25 - Related articles - BL Direct - All 4 versions
S Teno, H Kanno, S Oga, S Kumakura, R … - Diabetes research and …, 1999 - Elsevier Although most of patients with non-insulin-dependent diabetes mellitus (NIDDM) have insulin
resistance, it is unknown whether a molecule might interfere with insulin action. Membrane glycoprotein
PC-1 (plasma cell antigen-1), which inhibits insulin receptor tyrosine kinase activity, was ... Cited by 15 - Related articles - All 9 versions
S De Cosmo, A Argiolas, G Miscio, S Thomas … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Insulin resistance characterizes type 1 diabetes in patients with albuminuria. A PC-1 glycoprotein
amino acid variant, K121Q, is associated with insulin resis- tance. We examined the impact of
the PC-1 K121Q vari- ant on the rate of decline of the glomerular filtration rate (GFR) by ... Cited by 38 - Related articles - BL Direct - All 3 versions
