- ►diabetesjournals.org R Roduit, P Masiello, SP Wang, H Li, GA Mitchell, M … - Diabetes, 2001 - Am Diabetes Assoc Endogenous lipid stores are thought to be involved in the mechanism whereby the β-cell adapts
its secretory capacity in obesity and diabetes. In addition, hormone-sensitive lipase (HSL) is
expressed in β-cells and may provide fatty acids necessary for the generation of coupling ... Cited by 74 - Related articles - BL Direct - All 5 versions
H Mulder, M Sörhede-Winzell, JA Contreras, M Fex, … - Journal of Biological …, 2003 - ASBMB Lipid metabolism plays an important role in glucose homeostasis under normal and pathological
conditions. In adipocytes, skeletal muscle, and pancreatic β-cells, lipids are mobilized from acylglycerides
by the hormone-sensitive lipase (HSL). Here, the consequences of a targeted disruption ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] H Mulder, LS Holst, H Svensson, E Degerman, F … - Diabetes, 1999 - Am Diabetes Assoc Triglycerides in the -cell may be important for stim- ulus-secretion coupling, through provision
of a lipid- derived signal, and for pathogenetic events in NIDDM, where lipids may adversely
affect -cell function. In adipose tissues, hormone-sensitive lipase (HSL) is rate-limiting in ... Cited by 87 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MS Winzell, H Svensson, P Arner, B Ahrén, C Holm - Diabetes, 2001 - Am Diabetes Assoc Hormone-sensitive lipase (HSL) is expressed and enzymatically active in β-cells and has been
proposed to be involved in the generation of the lipid-derived signal that seems to be necessary
for glucose-stimulated insulin secretion. In this study, we investigated whether the ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier, BE … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in hormone-sensitive
lipase-null mice (HSL −/− ), both in vivo and in vitro. The focus of the current study was to gain
further insight into the signaling role and regulation of lipolysis in islet tissue. The effect of ... Cited by 34 - Related articles - BL Direct - All 6 versions
P Masiello, M Novelli, M Bombara, V Fierabracci, S … - Metabolism, 2002 - Elsevier This study intended to test the hypothesis that intracellular lipolysis in the pancreatic [beta ] cells
is implicated in the regulation of insulin secretion stimulated by nutrient secretagogues or cyclic
adenosine monophosphate (cAMP) agonists. Indeed, although lipid signaling molecules ... Cited by 26 - Related articles - BL Direct - All 7 versions
SP Wang, N Laurin, J Himms-Hagen, MA Rudnicki, E … - Obesity, 2001 - nature.com Results: Homozygous HSL -/- mice have no detectable HSL peptide or cholesteryl esterase activity
in adipose tissue, and heterozygous mice have intermediate levels with respect to wild-type and
deficient littermates. HSL-deficient mice have normal body weight but reduced abdominal ... Cited by 125 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org GC Yaney, VN Civelek, AM Richard, JS Dillon, JT … - Diabetes, 2001 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) is the most potent physiological incretin for insulin secretion
from the pancreatic β-cell, but its mechanism of action has not been established. It interacts with
specific cell-surface receptors, generates cAMP, and thereby activates protein kinase A ( ... Cited by 47 - Related articles - BL Direct - All 5 versions
GSI Secretion - DIABETES, 2001 - Am Diabetes Assoc Endogenous lipid stores are thought to be involved in the mechanism whereby the -cell adapts
its secretory capacity in obesity and diabetes. In addition, hormone- sensitive lipase (HSL) is
expressed in -cells and may provide fatty acids necessary for the generation of cou- pling ... Related articles
H Lindvall, P Nevsten, K Ström, R Wallenberg, F … - Journal of Biological …, 2004 - ASBMB Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization in many cell types.
Two isoforms of HSL are known to date, namely HSL adi (84 kDa in rat) and HSL tes (130 kDa
in rat). These are encoded by the same gene, with exons 1-9 encoding the parts that are ... Cited by 22 - Related articles - BL Direct - All 4 versions
