- ►diabetesjournals.org LL Kjems, BM Kirby, EM Welsh, JD Veldhuis, M … - Diabetes, 2001 - Am Diabetes Assoc Most insulin is secreted in discrete pulses at an interval of ∼6 min. Increased insulin secretion
after meal ingestion is achieved through the mechanism of amplification of the burst mass.
Conversely, in type 2 diabetes, insulin secretion is impaired as a consequence of ... Cited by 74 - Related articles - BL Direct - All 6 versions
MO Larsen, B Rolin, M Wilken, RD Carr, CF Gotfredsen - Diabetes, 2003 - Am Diabetes Assoc Knowledge about β-cell mass and/or function could be of importance for the early diagnosis
and treatment of diabetes. However, measurement of β-cell function as an estimate of β-cell mass
is currently the only method possible in humans. The present study was performed to ... Cited by 31 - Related articles - BL Direct - All 5 versions
MO Larsen, CF Gotfredsen, M Wilken, RD Carr, N … - Diabetologia, 2003 - Springer Aims/hypothesis. Type 2 diabetes is associated with impaired insulin action and secretion, including
dis- turbed pulsatile release. Impaired pulsatility has been related to impaired insulin action,
thus providing a possible link between release and action of insulin. Furthermore, ... Cited by 20 - Related articles - BL Direct - All 4 versions
CJ Goodner, DJ Koerker, DS Weigle, DK McCulloch - Diabetes, 1989 - Am Diabetes Assoc The effect of beta-cell deficiency on the spontaneous pulsatile secretory pattern of the islets of
Langerhans was studied in the baboon. Measures of beta-cell function were correlated with the
secretory pattern before and at intervals after streptozocin administration. The degree of ... Cited by 27 - Related articles - All 4 versions
AV Matveyenko, JD Veldhuis, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) often coexist and as such
represent a potent risk factor for subsequent development of type 2 diabetes. β-Cell mass is
∼50% deficient in IFG and ∼65% deficient in type 2 diabetes. To establish the effect of a ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►physiology.org MO Larsen, M Wilken, CF Gotfredsen, RD … - American Journal of …, 2002 - Am Physiological Soc Nonrodent models of diabetes are needed for practical and physiological reasons. Induction
of mild insulin-deficient diabetes was investigated in male Göttingen minipigs by use of streptozotocin
(STZ) alone (75, 100, and 125 mg/kg) or 125 mg/kg combined with pretreatment with ... Cited by 31 - Related articles - BL Direct - All 6 versions
RA Ritzel, AE Butler, RA Rizza, JD Veldhuis, PC … - Diabetes Care, 2006 - Am Diabetes Assoc In type 2 diabetes there is a progressive defect of insulin secretion that precedes the development
of hyperglycemia (1). This defect appears to be at least in part due to a deficit in β-cell mass
(2–4). Several therapeutic strategies are now being proposed that may reverse the defect ... Cited by 41 - Related articles - BL Direct - All 9 versions
N Porksen, S Munn, J Steers, JD Veldhuis, PC Butler - Diabetes, 1996 - Am Diabetes Assoc In the present studies, we used a recently validated canine model to determine 1) if glucose ingestion
stimulates insulin secretion by amplifying the pulsatile component of insulin release, and if
so, 2) whether this effect is achieved preferentially through burst mass or frequency ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►physiology.org MO Larsen, CB Juhl, N Porksen, CF … - American Journal of …, 2005 - Am Physiological Soc Herein, we bridge -cell function and morphology in minipigs. We hypothesized that different aspects
of -cell dysfunction are present in obesity and obesity with reduced -cell mass by using pulsatile
insulin secretion as an early marker. Measures for -cell function (glucose and arginine ... Cited by 13 - Related articles - All 4 versions
