SK Sreenan, YP Zhou, K Otani, PA Hansen, KPM … - Diabetes, 2001 - Am Diabetes Assoc Studies of the genetic basis of type 2 diabetes suggest that variation in the calpain-10 gene affects
susceptibility to this common disorder, raising the possibility that calpain-sensitive pathways
may play a role in regulating insulin secretion and/or action. Calpains are ubiquitously ... Cited by 111 - Related articles - BL Direct - All 5 versions
- ►nih.gov LJ Baier, PA Permana, X Yang, RE Pratley, … - Journal of Clinical …, 2000 - Am Soc Clin Investig Previous linkage studies in Mexican-Americans localized a major susceptibility locus for type
2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was recently
found to be associated with a common G→ A polymorphism (UCSNP-43) within the ... Cited by 257 - Related articles - BL Direct - All 8 versions
- ►nih.gov JC Evans, TM Frayling, PG Cassell, PJ Saker, GA … - The American Journal of …, 2001 - Elsevier Variation in CAPN10, the gene encoding the ubiquitously expressed cysteine protease
calpain-10, has been associated with type 2 diabetes in Mexican Americans and in two
northern-European populations, from Finland and Germany. We have studied CAPN10 in ... Cited by 137 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org S Lynn, JC Evans, C White, TM Frayling, AT Hattersley, … - Diabetes, 2002 - Am Diabetes Assoc Variation in the calpain-10 gene (CAPN10) has been shown to be associated with type 2 diabetes
in Mexican-Americans and in at least three Northern European populations. Studies in nondiabetic
Pima Indians showed that one of the at-risk DNA polymorphisms, single-nucleotide ... Cited by 69 - Related articles - BL Direct - All 6 versions
YP Zhou, S Sreenan, CY Pan, KPM Currie, VP … - Metabolism, 2003 - Elsevier Genetic variation in the gene for a cytosolic cysteine protease, calpain-10, increases the susceptibility
to type 2 diabetes apparently by altering levels of gene expression. In view of the importance
of altered [beta ]-cell function in the pathophysiology of type 2 diabetes, the present study ... Cited by 42 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org M Orho-Melander, M Klannemark, MK Svensson, M … - Diabetes, 2002 - Am Diabetes Assoc The calpain-10 gene (CAPN10) has been associated with type 2 diabetes, but information on
molecular and physiological mechanisms explaining this association is limited. Here we addressed
this question by studying the role of CAPN10 for phenotypes associated with type 2 ... Cited by 77 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org SK Rasmussen, SA Urhammer, L Berglund, JN Jensen, … - Diabetes, 2002 - Am Diabetes Assoc Variations in the calpain-10 gene (CAPN10) have been identified among
Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three
polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here ... Cited by 50 - Related articles - BL Direct - All 5 versions
DS Paul, AW Harmon, CP Winston, YM … - Biochemical Journal, 2003 - bj.portlandpress.com Calpains are a family of non-lysosomal cysteine proteases. Recent studies have identified a
member of the calpain family of proteases, calpain 10, as a putative diabetes-susceptibility gene
that may be involved in the development of type 2 diabetes. Inhibition of calpain activity ... Cited by 48 - Related articles - View as HTML - BL Direct - All 10 versions
H Ma, C Fukiage, YH Kim, MK Duncan, NA Reed, M … - Journal of Biological …, 2001 - ASBMB Calpains are calcium-dependent intracellular nonlysosomal proteases that are believed to hydrolyze
specific substrates important in calcium-regulated signaling pathways. Recently, an atypical
member of the calpain family, calpain 10, was described, and genetic variation in this ... Cited by 76 - Related articles - BL Direct - All 7 versions
M Stumvoll, A Fritsche, A Madaus, N Stefan, M Weisser, … - Diabetes, 2001 - Am Diabetes Assoc Recently, an association of the G allele in UCSNP-43 of calpain 10 with type 2 diabetes and
decreased glucose disposal was reported. Calpain 10 is also expressed in pancreatic islets.
It is not known, however, whether and how this polymorphism contributes to the biological ... Cited by 51 - Related articles - BL Direct - All 4 versions
