- ►diabetesjournals.org H Chen, EC Carlson, L Pellet, JT Moritz, PN … - Diabetes, 2001 - Am Diabetes Assoc The release of reactive oxygen species (ROS) has been proposed as a cause of
streptozotocin (STZ)-induced ß-cell damage. This initiates a destructive
cascade, consisting of DNA damage, excess activation of the DNA repair ... Cited by 55 - Related articles - BL Direct - All 5 versions
P Ohly, C Dohle, J Abel, J Seissler, H … - Diabetologia, 2000 - Springer (ROS) and nitrogen monoxide (NO) contribute to in- flammatory diseases [3] and
are implicated as media- torsofbeta-celldestructioninanimalmodelsofdiabe- tes
[4±11]. Reactive oxygen species are continuously produced by ... Cited by 38 - Related articles - BL Direct - All 4 versions
J Yang, MG Cherian - Life Sciences, 1994 - grande.nal.usda.gov Record Detail. Return to previous page, Save: Title: Protective effects of
metallothionein on streptozotocin-induced diabetes in rats. ... Cited by 42 - Related articles - Cached - BL Direct - All 4 versions
M Penkowa - Biomed Rev, 2002 - bgscb.org Metallothioneins (MTs) are low-molecular-weight (6–7 kD) nonenzymatic proteins
(60-68 amino acid residues, 25-30% being cysteine) ubiquitously expressed in the
animal kingdom. In the central nervous system (CNS), three MT isoforms are ... Cited by 12 - Related articles - View as HTML
X Li, H Chen, PN Epstein - Journal of Biological Chemistry, 2004 - ASBMB Islet transplantation is a promising therapy for Type 1 diabetes, but many
attempts have failed due to early graft hypoxia or immune rejection, which
generate reactive oxygen species (ROS). In the current study, we determined ... Cited by 66 - Related articles - BL Direct - All 5 versions
GK Andrews, K Kage, P Palmiter-Thomas, MP … - Pancreas, 1990 - grande.nal.usda.gov Record Detail. Return to previous page, Save: Title: Metal ions induce expression
of metallothionein in pancreatic exocrine and endocrine cells. ... Cited by 27 - Related articles - Cached - All 3 versions
B Xu, JT Moritz, PN Epstein - Free Radical Biology and Medicine, 1999 - Elsevier Pancreatic beta cells are sensitive to reactive oxygen species and this may play
an important role in type 1 diabetes and during transplantation. Beta cells
contain low levels of enzyme systems that protect against reactive oxygen ... Cited by 46 - Related articles - BL Direct - All 4 versions
- ►ebmonline.org E Ho, N Quan, YH Tsai, W Lai, TM Bray - Experimental Biology and Medicine, 2001 - SEBM Zinc status in patients with Type I diabetes is significantly lower than healthy
controls. Whether zinc supplementation can prevent the onset of Type I diabetes
is unknown. Recent studies have suggested that the generation of reactive ... Cited by 62 - Related articles - BL Direct - All 5 versions
Q Liang, EC Carlson, RV Donthi, PM Kralik, X … - Diabetes, 2002 - Am Diabetes Assoc Many diabetic patients suffer from cardiomyopathy, even in the absence of
vascular disease. This diabetic cardiomyopathy predisposes patients to heart
failure and mortality from myocardial infarction. Evidence from animal ... Cited by 89 - Related articles - BL Direct - All 4 versions
L Cai, MG Cherian - Toxicology letters, 2003 - Elsevier Protection of radiation-induced DNA damage by metallothionein (MT) has been
documented, but there is no detailed information about its efficiency compared
to other antioxidants or the effect of metals which bind to MT on the ... Cited by 38 - Related articles - All 9 versions
