PA Craven, MF Melhem, SL Phillips, FR DeRubertis - Diabetes, 2001 - Am Diabetes Assoc Ex vivo and in vitro observations implicate superoxide as a mediator of cell injury in
diabetes, but in vivo evidence is lacking. In the current studies, parameters of glomerular injury
were examined in hemizygous nondiabetic transgenic mice (SOD) and streptozotocin- ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org FR DeRubertis, PA Craven, MF Melhem, EM Salah - Diabetes, 2004 - Am Diabetes Assoc The effects of overexpression of Cu 2+ /Zn 2+ superoxide dismutase-1 (SOD-1) on indexes of
renal injury were compared in 5-month-old nontransgenic (NTg) db/db mice and db/db mice
hemizygous for the human SOD-1 transgene (SOD-Tg). Both diabetic groups exhibited ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org MF Melhem, PA Craven, J Liachenko, FR … - Journal of the American …, 2002 - Am Soc Nephrol ABSTRACT. Previous studies demonstrated that 2 mo of dietary supplementation with -lipoic
acid (LA) prevented early glomerular injury in non-insulin-treated streptozotocin diabetic rats
(D). The present study examined the effects of chronic LA supplementation (30 mg/kg ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org D Koya, K Hayashi, M Kitada, A Kashiwagi, R … - Journal of the American …, 2003 - Am Soc Nephrol Diabetic nephropathy is a leading cause of end-stage renal failure, accounting for 35 to 40%
of all new cases that require dialysis therapy worldwide. Recent clinical studies clearly demonstrated
that hyperglycemia is an important causal factor in mediating the development and ... Cited by 81 - Related articles - BL Direct - All 6 versions
PA Craven, SL Phillips, MF Melhem, J Liachenko, FR … - Metabolism, 2001 - Elsevier Superoxide has been implicated in the cellular signalling pathways, which regulate growth of
mesangial cells (MC) and vascular smooth muscle cells. Manganese (Mn) 2+ -dependent superoxide
dismutase (SOD-2) is primarily responsible for metabolism of superoxide produced in ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org MF MELHEM, PA CRAVEN, FR … - Journal of the American …, 2001 - Am Soc Nephrol Abstract. Antioxidants, in particular vitamin E (VE), have been reported to protect against diabetic
renal injury. -Lipoic acid (LA) has been found to attenuate diabetic peripheral neuropathy, but
its effects on nephropathy have not been examined. In the present study, parameters of ... Cited by 73 - Related articles - BL Direct - All 6 versions
FR DeRubertis, PA Craven, MF Melhem - Metabolism, 2007 - Elsevier Indices of renal injury and oxidative stress were examined in mice with deficiency of cytosolic
Cu 2+ /Zn 2+ superoxide dismutase (SOD1−/−, KO) and their wild-type (WT) littermates with
streptozotocin-induced diabetes. After 5 weeks of diabetes, KO diabetic (D) but not WT-D ... Cited by 12 - Related articles - All 10 versions
- ►asnjournals.org HB Lee, MR Yu, Y Yang, Z Jiang, H Ha - Journal of the American …, 2003 - Am Soc Nephrol Diabetic nephropathy is characterized by excessive deposition of extracellular matrix (ECM)
in the kidney, leading to glomerular mesangial expansion and tubulointerstitial fibrosis. Clinical
studies (1,2) have demonstrated that high blood glucose is the main determinant of ... Cited by 176 - Related articles - BL Direct - All 7 versions
RK Studer, PA Craven, FR DeRubertis - Metabolism, 1997 - Elsevier Protein kinase C (PKC)-signaled increases in transforming growth factor β (TGFβ) have been
implicated in the stimulation of matrix protein synthesis induced by high concentrations of
glucose, thromboxane, angiotension II (All), and other stimuli in cultured glomerular ... Cited by 116 - Related articles - BL Direct - All 8 versions
[CITATION] Effects of dietary supplementation with vitamin C or E on albuminuria, glomerular …
P Craven, R DeRubertis, VE Kagan, MF Melhem, RK … - J Am Soc Nephrol, 1997 Cited by 8 - Related articles
