SM Echwald, H Bach, H Vestergaard, B … - Diabetes, 2002 - Am Diabetes Assoc In the present study, we tested the hypothesis that variability in the protein
tyrosine phosphatase-1B (PTP-1B) gene is associated with type 2 diabetes. Using
single-strand conformational polymorphism analysis, we examined cDNA of ... Cited by 70 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Mok, H Cao, B Zinman, AJG Hanley, SB … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Several lines of evidence support a role for protein tyrosine phosphatase 1B
(PTP-1B) in metabolism, and specifically in insulin sensitivity and obesity. We
report the development of reagents for the amplification and sequencing of ... Cited by 63 - Related articles - BL Direct - All 6 versions
- ►nih.gov R Di Paola, L Frittitta, G Miscio, M Bozzali, R … - The American Journal of Human Genetics, 2002 - Elsevier Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling and, when
overexpressed, plays a role in insulin resistance (Ahmad et al. 1997). We
identified, in the 3′ untranslated region of the PTP1B gene, a 1484insG ... Cited by 103 - Related articles - BL Direct - All 4 versions
PKAL Forsell, Y Boie, J Montalibet, S Collins … - Gene, 2000 - Elsevier PTP-1B is a ubiquitously expressed intracellular protein tyrosine phosphatase
(PTP) that has been implicated in the negative regulation of insulin signaling.
Mice deficient in PTP-1B were found to have an enhanced insulin sensitivity ... Cited by 37 - Related articles - All 4 versions
SM Echwald, H Bach, H Vestergaard, B … - DIABETES, 2002 - Am Diabetes Assoc Page 1. Rapid Publication A P387L Variant in Protein Tyrosine Phosphatase-
1B (PTP-1B) Is Associated With Type 2 Diabetes and Impaired ... Related articles - All 2 versions
- ►pubget.com [PDF] JL Bento, ND Palmer, JC Mychaleckyj, LA … - Diabetes, 2004 - Am Diabetes Assoc The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48),
which negatively regulates insulin signaling by dephosphorylating the
phosphotyrosine residues of the insulin receptor kinase activation segment. ... Cited by 69 - Related articles - BL Direct - All 6 versions
ND Palmer, JL Bento, JC Mychaleckyj, CD … - DIABETES-NEW YORK-, 2004 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the
dephosphorylation of pro- teins at tyrosyl residues. PTP-1B has been implicated
in negatively regulating insulin signaling by dephosphory- lating the ... Cited by 45 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] J Weng, J Yan, Z Huang, Y Sui, L Xiu - Diabetes care, 2003 - Am Diabetes Assoc Type 2 diabetes is both a phenotypi- cally and geneotypically heteroge- neous
disease. It is caused by defective insulin secretion and action. Protein
tyrosine phosphatases (PTPases) play important roles in insulin cascade ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►shouxi.net JC Florez, CM Agapakis, NP Burtt, M Sun, P … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates
the insulin signal transduction cascade by dephosphorylating phosphotyrosine
residues in insulin signaling molecules. Due to its chromosomal location ... Cited by 25 - Related articles - All 8 versions
JE Clampit, JL Meuth, HT Smith, RM Reilly, … - Biochemical and Biophysical Research …, 2003 - Elsevier Protein-tyrosine phosphatase-1B (PTP1B) has been implicated as a negative
regulator of insulin signaling. PTP1B dephosphorylates the insulin receptor and
insulin receptor substrates (IRS-1/2), inhibiting the insulin-signaling ... Cited by 30 - Related articles - BL Direct - All 4 versions
