K Yamagata, T Nammo, M Moriwaki, A Ihara, K Iizuka, … - Diabetes, 2002 - Am Diabetes Assoc One subtype of maturity-onset diabetes of the young (MODY)-3 results from mutations in the
gene encoding hepatocyte nuclear factor (HNF)-1α. We generated transgenic mice expressing
a naturally occurring dominant-negative form of human HNF-1α (P291fsinsC) in ... Cited by 65 - Related articles - BL Direct - All 4 versions
K Yamagata, T Nammo, M Moriwaki, A Ihara, K Iizuka, … - Diabetes, 2002 - Am Diabetes Assoc Page 1. Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear
Factor-1 in Pancreatic -Cells Causes Abnormal Islet Architecture With Decreased
Expression of E-Cadherin, Reduced -cell Proliferation, and Diabetes ... Cited by 15 - Related articles
- ►endojournals.org KA Hagenfeldt-Johansson, PL Herrera, H Wang, A … - Endocrinology, 2001 - Endocrine Soc Mutations in the transcription factor hepatocyte nuclear factor-1 (HNF-1 ) cause maturity-onset
diabetes of the young 3, a severe form of diabetes characterized by pancreatic ß-cell
dysfunction. We have used targeted expression of a dominant-negative mutant of HNF-1 ... Cited by 40 - Related articles - BL Direct - All 2 versions
H Wang, PA Antinozzi, KA Hagenfeldt, P … - The EMBO …, 2000 - pubmedcentral.nih.gov The reverse tetracycline-dependent transactivator system was employed in insulinoma INS-1
cells to achieve controlled inducible expression of hepatocyte nuclear factor-1α
(HNF1α)-P291fsinsC, the most common mutation associated with subtype 3 of maturity- ... Cited by 81 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org Q Yang, K Yamagata, K Fukui, Y Cao, T Nammo, H … - Diabetes, 2002 - Am Diabetes Assoc Maturity-onset diabetes of the young type 3 (MODY3) is characterized by impaired insulin
secretion. Heterozygous mutations in the gene encoding hepatocyte nuclear factor (HNF)-1α
are the cause of MODY3. Transgenic mice overexpressing dominant-negative HNF-1α ... Cited by 26 - Related articles - BL Direct - All 5 versions
DQ Shih, S Screenan, KN Munoz, L Philipson, M … - Diabetes, 2001 - Am Diabetes Assoc Mutations in hepatocyte nuclear factor 1α (HNF-1α) lead to maturity-onset diabetes of the young
type 3 as a result of impaired insulin secretory response in pancreatic β-cells. The expression
of 50 genes essential for normal β-cell function was studied to better define the molecular ... Cited by 142 - Related articles - BL Direct - All 5 versions
ID Dukes, S Sreenan, MW Roe, M Levisetti, YP … - Journal of Biological …, 1998 - ASBMB Mutations in the hepatocyte nuclear factor-1α (HNF-1α) gene cause maturity onset diabetes of
the young type 3, a form of type 2 diabetes mellitus. In mice lacking the HNF-1α gene, insulin
secretion and intracellular calcium ([Ca 2+ ] i ) responses were impaired following ... Cited by 123 - Related articles - BL Direct - All 6 versions
H Wobser, H Düßmann, D Kögel, H Wang, C … - Journal of Biological …, 2002 - ASBMB Maturity onset diabetes of the young (MODY) 3 is a monogenic form of diabetes caused by mutations
in the transcription factor hepatocyte nuclear factor (HNF)-1α. We investigated the involvement
of apoptotic events in INS-1 insulinoma cells overexpressing wild-type HNF-1α ... Cited by 29 - Related articles - BL Direct - All 5 versions
D Bosco, L Orci, P Meda - Experimental Cell Research, 1989 - Elsevier To assess whether and how specifically contact influences the functioning of differentiated
cells, we have studied the secretion of adult pancreatic B-cells as a function of aggregation to
either homologous B-cells or other heterologous endocrine islet cell types, all present in a ... Cited by 69 - Related articles - All 3 versions
