- ►diabetesjournals.org H Dong, J Altomonte, N Morral, M Meseck, … - Diabetes, 2002 - Am Diabetes Assoc Although a conventional insulin regimen for type 1 diabetes with twice-daily
insulin injections is effective in preventing postprandial blood glucose
excursions, this treatment is limited by its inadequate control of fasting ... Cited by 24 - Related articles - BL Direct - All 5 versions
H Dong, N Morral, R McEvoy, M Meseck, SN … - Diabetes research and clinical practice, 2001 - Elsevier Low levels of hepatic insulin production have been shown to prevent lethal
ketoacidosis associated with type 1 diabetes. To assess the beneficial effects
of sustained hepatic production of insulin on glycemic control in type 1 ... Cited by 30 - Related articles - All 6 versions
A Sugiyama, S Hattori, S Tanaka, F Isoda, S … - Hormone and metabolic research, 1997 - thieme-connect.com The present study assessed the feasibility of transferring the insulin gene into
liver cells of diabetic individuals using a defective adenoassociated viral
(AAV) vehicle. AAV offers several advantages over other viral vectors, ... Cited by 30 - Related articles - BL Direct - All 3 versions
AL Shifrin, A Auricchio, QC Yu, J Wilson, SE … - Gene therapy(Basingstoke), 2001 - cat.inist.fr Therapy for type 1 diabetes consists of tight blood glucose(BG) control to
minimize complications. Current treatment relies on multiple insulin injections
or an insulin pump placement, β-cell or whole pancreas transplantation. ... Cited by 31 - Related articles - BL Direct - All 4 versions
S Nagamatsu, Y Nakamichi, M Ohara-Imaizumi … - FEBS letters, 2001 - Elsevier We investigated whether adenovirus-mediated preproinsulin gene transfer into
insulin target tissues (adipocytes) ameliorates hyperglycemia in diabetic mice.
KKA y mice, a genetically obese type 2 diabetic animal model, were treated ... Cited by 22 - Related articles - All 4 versions
E Riu, A Mas, T Ferre, A Pujol, L Gros, P … - Diabetes, 2002 - Am Diabetes Assoc Insulin replacement therapy in type 1 diabetes is imperfect because proper
glycemic control is not always achieved. Most patients develop microvascular,
macrovascular, and neurological complications, which increase with the ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►endojournals.org P Muzzin, RC Eisensmith, KC Copeland, … - Molecular Endocrinology, 1997 - Endocrine Soc Type 1 diabetes mellitus is caused by a lack of insulin that results from the
autoimmune destruction of the pancreatic ß-cells. Severe diabetes, if not
controlled by periodic insulin injections, can lead to ketoacidosis and ... Cited by 52 - Related articles - BL Direct - All 4 versions
RM Jindal, M Karanam, R Shah - International journal of experimental diabetes research, 2001 - pubmedcentral.nih.gov Using the Adeno-associated virus (AAV) as a gene delivery vehicle, we have
constructed a recombinant vector containing the full length rat preproinsulin
gene (vLP-1). Utilizing the well described non-obese diabetic (NOD) mouse ... Cited by 10 - Related articles - All 5 versions
OL Kon, S Sivakumar, KL Teoh, SHL Lok, YC … - The Journal of Gene Medicine, 1999 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 33 - Related articles - BL Direct - All 2 versions
R Morishita, GH Gibbons, Y Kaneda, T … - Biochemical and Biophysical Research …, 2000 - Elsevier In this study, we examined the feasibility of a systemic administration of
HVJ-liposome complex containing human insulin construct into the blood in mice
via the tail vein. Transfection of human insulin vector resulted in a ... Cited by 14 - Related articles - BL Direct - All 4 versions
