- ►diabetesjournals.org G Mithieux, L Guignot, JC Bordet, N Wiernsperger - Diabetes, 2002 - Am Diabetes Assoc The aim of this study was to understand by which intrahepatic mechanism metformin (Met) may
inhibit basal hepatic glucose production (HGP) in type 2 diabetes. We studied rats that were
fed for 6 weeks a high-fat (HF) diet, supplemented (HF-Met) or not (HF) with Met (50 mg · ... Cited by 41 - Related articles - BL Direct - All 5 versions
J Radziuk, Z Zhang, N Wiernsperger, S Pye - Diabetes, 1997 - Am Diabetes Assoc To directly assess the effects of the biguanide, metformin, on hepatic gluconeogenesis, it was
added at high therapeutic levels (90 microg/ml) to the medium perfusing an isolated rat liver.
Lactate (1 mg/min) was infused simultaneously along with [14C]lactate with or without [3H] ... Cited by 50 - Related articles - BL Direct - All 4 versions
F Rajas, N Bruni, S Montano, C Zitoun, G Mithieux - Gastroenterology, 1999 - Elsevier Glucose-6 phosphatase (Glc6Pase) (EC 3.1.3.9) is a crucial enzyme involved in blood glucose
homeostasis. It catalyzes the hydrolysis of glucose-6 phosphate to glucose and inorganic phosphate
(Pi). This is the last biochemical reaction common to both gluconeogenesis and ... Cited by 53 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org [PDF] V Large, M Beylot - Diabetes, 1999 - Am Diabetes Assoc To better define the modifications of liver gluconeoge- nesis and citric acid cycle, or Krebs'
cycle, activity induced by insulin deficiency and the effects of met- formin on these
abnormalities, we infused livers iso- lated from postabsorptive or starved normal and ... Cited by 33 - Related articles - BL Direct - All 4 versions
PT Fueger, DP Bracy, CM Malabanan, RR Pencek, DK … - Diabetes, 2004 - Am Diabetes Assoc The aim of the present study was to determine the specific sites of impairment to muscle glucose
uptake (MGU) in the insulin-resistant high-fat-fed, conscious C57BL/6J mouse. Wild type
(WT) and hexokinase II overexpressing (HK Tg ) mice were fed either a standard diet or ... Cited by 28 - Related articles - BL Direct - All 4 versions
JP Fulgencio, C Kohl, J Girard, JP Pégorier - Biochemical pharmacology, 2001 - Elsevier The short-term effect of metformin on fatty acid and glucose metabolism was studied in freshly
incubated hepatocytes from 24-hr starved rats. Metformin (5 or 50 mM) had no effect on oleate
or octanoate oxidation rates (CO 2 + acid-soluble products), whatever the concentration ... Cited by 32 - Related articles - BL Direct - All 4 versions
N Daniele, F Rajas, B Payrastre, G Mauco, C Zitoun … - Journal of Biological …, 1999 - ASBMB By using a rapid procedure of isolation of microsomes, we have shown that the liver
glucose-6-phosphatase activity was lowered by about 30% (p < 0.001) after refeeding for 360
min rats previously unfed for 48 h, whereas the amount of glucose-6-phosphatase protein ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] F Rajas, M Croset, C Zitoun, S Montano, G Mithieux - Diabetes, 2000 - Am Diabetes Assoc PEPCK is a key enzyme of gluconeogenesis in liver and kidney. Recently, we have shown that
small intestine also contributes to the endogenous glucose production in insulinopenia in rats
and that glutamine is the main precursor of glucose synthesized in this tissue. The ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Croset, F Rajas, C Zitoun, JM Hurot, S Montano, G … - Diabetes, 2001 - Am Diabetes Assoc At variance with the current view that only liver and kidney are gluconeogenic organs, because
both are the only tissues to express glucose-6-phosphatase (Glc6Pase), we have recently demonstrated
that the Glc6Pase gene is expressed in the small intestine in rats and humans and that it ... Cited by 68 - Related articles - BL Direct - All 4 versions
C Minassian, S Tarpin, G Mithieux - Biochemical pharmacology, 1998 - Elsevier We investigated the role of glucose-6 phosphatase (Glc6Pase), glucokinase (GK), and
glucose-6 phosphate (Glc6P) in liver insulin resistance, an early characteristic of type 2
diabetes, and its correction by metformin. We determined hepatic glucose production ... Cited by 27 - Related articles - BL Direct - All 5 versions
