- ►diabetesjournals.org AV Greco, G Mingrone, A Giancaterini, M Manco, M … - Diabetes, 2002 - Am Diabetes Assoc Obesity is a frequent cause of insulin resistance and poses a major risk for diabetes. Abnormal
fat deposition within skeletal muscle has been identified as a mechanism of obesity-associated
insulin resistance. We tested the hypothesis that dietary lipid deprivation may selectively ... Cited by 228 - Related articles - BL Direct - All 9 versions
G Mingrone, A DeGaetano, AV Greco, E Capristo, G … - Diabetologia, 1997 - Springer Therefore, obesity and its related disorders constitute one of the most relevant health and social
problems of the present era because of the high cost and dis- ability which it imposes on the
individual and the community [3–5]. Insulin resistance is a prominent biological marker of ... Cited by 90 - Related articles - BL Direct - All 3 versions
S Jacob, J Machann, K Rett, K Brechtel, A … - DIABETES-NEW …, 1999 - Am Diabetes Assoc Insulin resistance plays an important role in the patho- genesis of type 2 diabetes; however, the
multiple mech- anisms causing insulin resistance are not yet fully understood. The aim of this
study was to explore the pos- sible contribution of intramyocellular lipid content in the ... Cited by 361 - Related articles - BL Direct - All 4 versions
AV Greco, G Mingrone, R Vettor, M Manco, G … - Journal of Investigative …, 2002 - journals.lww.com Background: Our aim was to investigate the regulation of the gene expression of leptin in subcutaneous
adipose tissue biopsies in morbid obesity before and after biliopancreatic diversion (BPD).
Methods: Longitudinal study in morbidly obese subjects investigated twice: before and 6 ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►endojournals.org BH Goodpaster, J He, S Watkins, DE Kelley - Journal of Clinical …, 2001 - Endocrine Soc We examined the hypothesis that an excess accumulation of intramuscular lipid (IMCL) is associated
with insulin resistance and that this may be mediated by the oxidative capacity of muscle. Nine
sedentary lean (L) and 11 obese (O) subjects, 8 obese subjects with type 2 diabetes ... Cited by 296 - Related articles - BL Direct - All 5 versions
BH Goodpaster, R Theriault, SC Watkins, DE Kelley - Metabolism, 2000 - Elsevier The triglyceride content of skeletal muscle samples determined by lipid extraction correlates
with the severity of insulin-resistant glucose metabolism in muscle. To determine whether this
reflects increased triglyceride within muscle fibers and to test the-hypothesis that the lipid ... Cited by 158 - Related articles - BL Direct - All 3 versions
A Virkamäki, E Korsheninnikova, A Seppälä-Lindroos, … - Diabetes, 2001 - Am Diabetes Assoc To examine whether and how intramyocellular lipid (IMCL) content contributes to interindividual
variation in insulin action, we studied 20 healthy men with no family history of type 2
diabetes. IMCL was measured as the resonance of intramyocellular CH 2 protons in lipids/ ... Cited by 148 - Related articles - BL Direct - All 6 versions
- ►physiology.org RE Gray, CJ Tanner, WJ Pories, KG … - American Journal of …, 2003 - Am Physiological Soc The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular
lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained
from morbidly obese individuals [body mass index (BMI) 52.2 ± 2.5 kg/m 2 ; n = 6] before ... Cited by 40 - Related articles - BL Direct - All 5 versions
M Krssak, K Falk Petersen, A Dresner, L DiPietro, SM … - Diabetologia, 1999 - Springer Skeletal muscle insulin resistance is a common fea- ture of obesity, dyslipidaemia and arterial
hyperten- sion, and it is an important predisposing factor for Type II (non-insulin-dependent)
diabetes mellitus and premature cardiovascular disease [1]. Evidence has been provided ... Cited by 558 - Related articles - BL Direct - All 6 versions
N Scopinaro, E Gianetta, D Civalleri, U Bonalumi, V … - Br J Surg, 1979 - interscience.wiley.com After a successful trial of bilio-pancreatic bypass in dogs, a clinical study has been completed
in 18 patients followed for more than 1 year. The operation has been modified to achieve the
best weight reduction, and forming the bilio-pancreatic tract of equal length to the ... Cited by 221 - Related articles - All 4 versions
