- ►diabetesjournals.org Y Ido, D Carling, N Ruderman - Diabetes, 2002 - Am Diabetes Assoc Apoptosis has been observed in vascular cells, nerve, and myocardium of diabetic
humans and experimental animals, although whether it contributes to or is a
marker of complications in these tissues is unclear. Previous studies have ... Cited by 161 - Related articles - BL Direct - All 5 versions
C Blázquez, MJH Geelen, G Velasco, M … - FEBS letters, 2001 - Elsevier Fatty acids induce apoptosis in primary astrocytes by enhancing ceramide
synthesis de novo. The possible role of the AMP-activated protein kinase (AMPK)
in the control of apoptosis was studied in this model. Long-term ... Cited by 104 - Related articles - All 7 versions
C Stefanelli, I Stanic', F Bonavita, F Flamigni, … - Biochemical and Biophysical Research …, 1998 - Elsevier The AMP-activated protein kinase (AMPK) is related to a growing family of
protein kinases that are believed to protect cells against environmental and
nutritional stress. In the present study the hypothesis of a protective ... Cited by 59 - Related articles - BL Direct - All 5 versions
D Meisse, M Van de Casteele, C Beauloye, I … - FEBS letters, 2002 - Elsevier The aim of this work was to study the effect of a sustained activation of
AMP-activated protein kinase (AMPK) on liver cell survival. AMPK activation was
achieved by incubating FTO2B cells with AICA-riboside, which is transformed ... Cited by 74 - Related articles - All 7 versions
- ►ahajournals.org Z Dagher, N Ruderman, K Tornheim, Y Ido - Circulation research, 2001 - Am Heart Assoc Abstract—It is generally accepted that endothelial cells generate most of
their ATP by anaerobic glycolysis and that very little ATP is derived from the
oxidation of fatty acids or glucose. Previously, we have reported that, in ... Cited by 60 - Related articles - BL Direct - All 5 versions
Z Dagher, N Ruderman, K Tornheim, Y Ido - Biochemical and Biophysical Research …, 1999 - Elsevier In several non-vascular tissues in which it has been studied, AMP-activated
protein kinase (AMPK) appears to modulate the cellular response to stresses such
as ischemia. In liver and muscle, it phosphorylates and inhibits acetyl CoA ... Cited by 52 - Related articles - BL Direct - All 5 versions
JM Cacicedo, N Yagihashi, JF Keaney, NB … - Biochemical and Biophysical Research …, 2004 - Elsevier The fuel sensing enzyme AMP-activated protein kinase (AMPK) enhances processes
that generate ATP when stresses such as exercise or glucose deprivation make
cells energy deficient. We report here a novel role of AMPK, to prevent the ... Cited by 72 - Related articles - All 4 versions
N Ruderman, J Cacicedo, S Itani, N Yagihashi … - Biochemical Society Transactions, 2003 - bst.portlandpress.com Based on available evidence, we would propose the following. (i) Excesses of
glucose and free fatty acids cause insulin resistance in skeletal muscle and
damage to the endothelial cell by a similar mechanism. (ii) Key ... Cited by 77 - Related articles - Cached - BL Direct - All 10 versions
- ►bloodjournal.org C Campas, JM Lopez, AF Santidrian, M … - Blood, 2003 - Am Soc Hematology Previous studies report that acadesine inhibits glucocorticoid-induced apoptosis
in quiescent thymocytes, 16 apoptosis caused by serum deprivation in fibroblasts
overproducing fructose 2,6-bisphosphate, 17 and ceramide-induced apoptosis ... Cited by 60 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org E Schulz, E Anter, MH Zou, JF Keaney Jr - Circulation, 2005 - Am Heart Assoc Methods and Results— Porcine aortic endothelial cells exhibited time- and
concentration-dependent AMPK activation as determined by phosphorylation of AMPK
and its downstream target acetyl coenzyme A carboxylase in response to ... Cited by 57 - Related articles - All 10 versions
