- ►diabetesjournals.org C Vecchione, A Maffei, S Colella, A Aretini, R … - Diabetes, 2002 - Am Diabetes Assoc Recent evidence suggests that besides its action on the central nervous system,
leptin can modulate vascular tone through local mechanisms involving nitric
oxide (NO) release. In this study, using a fluorescent probe for direct ... Cited by 162 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] G Lembo, C Vecchione, L Fratta, G Marino, V … - Diabetes, 2000 - Am Diabetes Assoc In this study, we reveal that leptin evokes an acute hypotensive effect in
6-hydroxydopamine sympathec- tomized rats (response to maximal leptin dose, mean
blood pressure: from 92 ± 4 to 78 ± 2 mmHg, P < 0.01). This hemodynamic ... Cited by 171 - Related articles - BL Direct - All 4 versions
G Frühbeck - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc Leptin administration has been shown to increase renal, adrenal, and lumbar
sympathetic nerve activity. H owever, this generalized sympathoexcitatory
activity is not always followed by an increase in arterial pres- sure. The ... Cited by 217 - Related articles - BL Direct - All 5 versions
K Matsuda, H Teragawa, Y Fukuda, K … - Hypertension research: official journal of the Japanese …, 2003 - ncbi.nlm.nih.gov Recent studies have shown that leptin causes vasodilation. However, it is
unclear whether leptin causes coronary vasodilation in humans. To determine how
leptin affects human coronary arteries and whether endothelium-derived ... Cited by 45 - Related articles - BL Direct - All 2 versions
K Kimura, K Tsuda, A Baba, T Kawabe, S Boh- … - Biochemical and Biophysical Research …, 2000 - Elsevier Leptin is a polypeptide, mainly produced in white adipose tissue, and increases
sympathetic nerve activity. A few studies investigated leptin's effect on
peripheral vessels. We examined the vasorelaxant effects of human leptin on ... Cited by 119 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org JL Mitchell, DA Morgan, MLG Correia, AL … - Hypertension, 2001 - Am Heart Assoc Abstract—— Leptin decreases appetite and increases sympathetic nerve
activity and arterial pressure. Recent reports suggest that leptin may also have
peripheral vasodilator actions that would tend to reduce arterial pressure. ... Cited by 43 - Related articles - BL Direct - All 6 versions
K Nakagawa, Y Higashi, S Sasaki, T Ohshima … - HBPR Council Meeting Abstracts, 2000 - Am Heart Assoc Background: Recently, it was reported that the acute infusion of the leptin
markedly increased sympathetic nerve activity, but did not change arterial
pressure, and it was also reported that the leptin receptor was expressed ... Cited by 54 - Related articles - BL Direct - All 4 versions
- ►physiology.org B Winters, Z Mo, E Brooks-Asplund, S Kim, A … - Journal of Applied Physiology, 2000 - Am Physiological Soc Obesity is a major health care problem and is associated with significant
cardiovascular morbidity. Leptin, a neuroendocrine hormone released by adipose
tissue, is important in modulating obesity by signaling satiety and ... Cited by 84 - Related articles - BL Direct - All 4 versions
J Beltowski… - Obesity, 2002 - nature.com Results: Leptin increased plasma concentrations of NO metabolites (nitrates +
nitrites, NO x ) by 32.5%, 58.0%, and 29.7% at 1, 2, and 4 hours, respectively.
Urinary NO x excretion increased by 28.8% in the first and by 20.1% in the ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org P Quehenberger, M Exner, R Sunder- … - Circulation research, 2002 - Am Heart Assoc Leptin, a protein encoded by the obese gene, is produced by adipocytes and
released into the bloodstream. In obese humans, serum leptin levels are
increased and correlate with the individual's body mass index and blood ... Cited by 166 - Related articles - BL Direct - All 6 versions
