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Scholar Results 1 - 10 of about 101 related to Liang: Overexpression of metallothionein reduces diabetic cardiomyopathy. (0.10 sec) 

Overexpression of metallothionein reduces diabetic cardiomyopathy


Q Liang, EC Carlson, RV Donthi, PM Kralik, X … - Diabetes, 2002 - Am Diabetes Assoc
Many diabetic patients suffer from cardiomyopathy, even in the absence of
vascular disease. This diabetic cardiomyopathy predisposes patients to heart
failure and mortality from myocardial infarction. Evidence from animal ...
Cited by 89 - Related articles - BL Direct - All 4 versions

Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive …

- uwyo.edu [PDF] 
G Ye, NS Metreveli, J Ren, PN Epstein - Diabetes, 2003 - Am Diabetes Assoc
Many individuals with diabetes experience impaired cardiac contractility that
cannot be explained by hypertension and atherosclerosis. This cardiomyopathy may
be due to either organ-based damage, such as fibrosis, or to direct damage ...
Cited by 105 - Related articles - BL Direct - All 5 versions

Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes


G Ye, NS Metreveli, RV Donthi, S Xia, M Xu, … - Diabetes, 2004 - Am Diabetes Assoc
Many diabetic patients suffer from a cardiomyopathy that cannot be explained by
poor coronary perfusion. Reactive oxygen species (ROS) have been proposed to
contribute to this cardiomyopathy. Consistent with this we found evidence ...
Cited by 61 - Related articles - BL Direct - All 4 versions

Inhibition of superoxide generation and associated nitrosative damage is involved in …

- shouxi.net
L Cai, J Wang, Y Li, X Sun, L Wang, Z Zhou, … - Diabetes, 2005 - Am Diabetes Assoc
The mechanisms of metallothionein prevention of diabetic cardiomyopathy are
largely unknown. The present study was performed to test whether inhibition of
nitrosative damage is involved in metallothionein prevention of diabetic ...
Cited by 60 - Related articles - All 5 versions

Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial …

- onlinejacc.org
L Cai, Y Wang, G Zhou, T Chen, Y Song, X Li, … - Journal of the American College of Cardiology, 2006 - Elsevier
Our previous study showed that cardiac apoptosis as a major early cellular
response to diabetes is induced by hyperglycemia-derived oxidative stress that
activates a mitochondrial cytochrome c-mediated caspase-3 activation ...
Cited by 50 - Related articles - BL Direct - All 20 versions

Oxidative stress and diabetic cardiomyopathy


L Cai, YJ Kang - Cardiovascular Toxicology, 2001 - Springer
*Author to whom all correspondence and reprint requests should be addressed: Y.
James Kang, Department of Medicine, University of Louisville School of Medicine,
511 S. Floyd St., MDR 530, Louisville, KY 40202. E-mail: yjkang01@athena. ...
Cited by 108 - Related articles - All 3 versions

Cardiac metallothionein induction plays the major role in the prevention of diabetic …

- ahajournals.org
J Wang, Y Song, L Elsherif, Z Song, G Zhou, … - Circulation, 2006 - Am Heart Assoc
Methods and Results— Diabetes was induced in mice (C57BL/6J strain) by a
single injection of streptozotocin. Half were supplemented intraperitoneally
with zinc sulfate (5 mg/kg) every other day for 3 months. After zinc ...
Cited by 43 - Related articles - All 10 versions

Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes


PM Kralik, G Ye, NS Metreveli, X Shen, PN … - Cardiovascular Toxicology, 2005 - Springer
*Author to whom all correspondence and reprint requests should be addressed:
E-mail: paul.epstein@ louisville.eduu. Received: 2/8/05 Revised: 3/28/05
Accepted: 3/29/05 Cardiovascular Toxicology, vol. 5, no. 3, 285–292, 2005
Cited by 14 - Related articles - BL Direct - All 4 versions

Suppression of nitrative damage by metallothionein in diabetic heart contributes to the …


L Cai - Free Radical Biology and Medicine, 2006 - Elsevier
Diabetic cardiomyopathy has become a major contributor to the increased
mortality of diabetic patients. Although the development and progression of
diabetic cardiomyopathy are considered to be associated with ...
Cited by 22 - Related articles - All 6 versions

Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection …

- amjpathol.org
Y Song, J Wang, Y Li, Y Du, GE Arteel, JT … - American Journal of Pathology, 2005 - ASIP
Oxidative stress is involved in the pathogenesis of diabetes and its
cardiovascular complications. Metallothionein (MT), a stress-response protein,
is significantly increased in the liver and kidney of diabetic animals. We ...
Cited by 35 - Related articles - All 11 versions


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