M Grattan, QS Mi, C Meagher, TL Delovitch - Diabetes, 2002 - Am Diabetes Assoc Twenty diabetes susceptibility loci on 12 mouse chromosomes have been identified
to control the development of type 1 diabetes at the level of either initiation
of insulitis or progression from insulitis to overt diabetes or both. ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org EA Ivakine, CJ Fox, AD Paterson, SM Mortin- … - The Journal of Immunology, 2005 - Am Assoc Immnol Many human autoimmune diseases are more frequent in females than males, and
their clinical severity is affected by sex hormone levels. A strong female bias
is also observed in the NOD mouse model of type I diabetes (T1D). In both ... Cited by 14 - Related articles - All 5 versions
UC Rogner, C Boitard, J Morin, E Melanitou, … - Genomics, 2001 - Elsevier The development of insulin-dependent diabetes mellitus in both human and mouse
is dependent on the interaction between genetic and environmental factors. The
analysis of newly created NOD.C3H congenic strains for spontaneous and ... Cited by 47 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org DV Serreze, M Bridgett, HD Chapman, E Chen … - The Journal of Immunology, 1998 - Am Assoc Immnol Although they share 88% of their genome with NOD mice including the H2 g7
haplotype, NOR mice remain free of T cell-mediated autoimmune diabetes (IDDM),
due to non-MHC genes of C57BLKS/J (BKS) origin. NOR IDDM resistance was ... Cited by 69 - Related articles - All 3 versions
TC Brodnicki, P McClive, S Couper, G … - Immunogenetics, 2000 - Springer Abstract Type 1 diabetes is a multigenic autoimmune disease, the genetic basis
for which is perhaps best char- acterized in the nonobese diabetic (NOD) mouse
mod- el. We previously located a NOD diabetes susceptibility locus, ... Cited by 20 - Related articles - BL Direct - All 2 versions
M McDuffie - Clinical Immunology, 2000 - Elsevier Autoimmune diabetes is a polygenic disease process in man and rodents. To
identify and characterize genes involved in the pathogenesis of diabetes in
nonobese diabetic (NOD) mice, we initiated a repetitive backcross of ... Cited by 22 - Related articles - BL Direct - All 5 versions
PA Lyons, WW Hancock, P Denny, CJ Lord, NJ … - Immunity, 2000 - Elsevier Previous analyses of NOD mice have shown that some genes control the development
of both insulitis and diabetes, while other loci influence diabetes without
reducing insulitis. Evidence for the existence of a gene only influencing ... Cited by 108 - Related articles - BL Direct - All 5 versions
- ►nih.gov EE Hamilton-Williams, DV Serreze, B Charlton … - Proceedings of the National Academy of Sciences of …, 2001 - National Acad Sciences Type 1 diabetes in both humans and nonobese diabetic (NOD) mice results from
T-cell-mediated autoimmune destruction of insulin-producing pancreatic β cells.
Linkage studies have shown that type 1 diabetes in NOD mice is a polygenic ... Cited by 60 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] NJ Hill, PA Lyons, N Armitage, JA Todd, LS … - Diabetes, 2000 - Am Diabetes Assoc A genome scan for B10-derived loci that reduce the fre- quency of diabetes and
insulitis in NOD mice demon- strated a large region (34 cM) of linkage on the
proxi- mal end of chromosome 1. This locus was designated Idd5 and ... Cited by 127 - Related articles - BL Direct - All 4 versions
SE Lamhamedi-Cherradi, O Boulard, C Gonzalez … - Diabetes, 2001 - Am Diabetes Assoc The Idd5 locus for autoimmune diabetes in nonobese diabetic (NOD) mice has been
mapped to the proximal half of chromosome 1 and appears to include two loci,
Idd5.1 and Idd5.2, Idd5.1 being a candidate homolog of the human IDDM12 ... Cited by 28 - Related articles - BL Direct - All 4 versions
