T Yasuda, Y Kajimoto, Y Fujitani, H Watada … - Diabetes, 2002 - Am Diabetes Assoc A paired homeodomain transcription factor, PAX6, is a well-known regulator of
eye development, and its heterozygous mutations in humans cause congenital eye
anomalies such as aniridia. Because it was recently shown that PAX6 also ... Cited by 50 - Related articles - BL Direct - All 5 versions
R Ashery-Padan, X Zhou, T Marquardt, P … - Developmental Biology, 2004 - Elsevier Pax6 transcription factor is required for islet cell number, morphology, and
hormone gene expression. The perinatal lethality of Pax6 null mutants has
restricted investigation of the role of Pax6 in normal endocrine cell ... Cited by 45 - Related articles - All 3 versions
M Nishi, M Sasahara, T Shono, S Saika, Y … - Diabetic Medicine, 2005 - interscience.wiley.com Case report A 27-year-old woman was referred to our clinic. She was diagnosed
having diabetes at the age of 15 with negative glutamic acid decarboxylase (GAD)
antibody. Insulin treatment was started at age 24. Because she had ... Cited by 7 - Related articles - All 4 versions
A Hamasaki, Y Yamada, T Kurose, N Ban, K … - Biochemical and Biophysical Research …, 2007 - Elsevier Pax6, a paired homeodomain transcription factor, plays crucial roles in
morphogenesis of eye, central nervous system, and pancreatic islets. Recently,
heterozygosity for pax6 mutation has been reported in some individuals with ... Cited by 8 - Related articles - All 6 versions
- ►jbc.org SE Samaras, L Zhao, A Means, E Henderson, … - Journal of Biological Chemistry, 2003 - ASBMB Pancreatic duodenal homeobox factor-1, PDX-1, is required for pancreas
development, islet cell differentiation, and the maintenance of cell function.
Selective expression in the pancreas appears to be principally regulated by ... Cited by 42 - Related articles - BL Direct - All 4 versions
TJ McCulley, K Mayer, SS Dahr, J Simpson, … - Eye, 2004 - nature.com Eye is the official journal of the Royal College of Ophthalmologists. It aims to
provide the practising ophthalmologist with information on the latest clinical ... Cited by 10 - Related articles - All 4 versions
DM Meisler, VL Perez, J Proudfit - American journal of ophthalmology, 2005 - Elsevier The device is composed of a pedestal with a convex surface mounted to a flat
platform. A corneoscleral button placed endothelial side down and centrally upon
the convexity is secured by suction conveyed through a hollowed core in the ... Cited by 5 - Related articles - All 16 versions
M Sander, A Neubüser, J Kalamaras, HC Ee, … - Genes & development, 1997 - genesdev.cshlp.org We present genetic and biochemical evidence that PAX6 is a key regulator of
pancreatic islet hormone gene transcription and is required for normal islet
development. In embryos homozygous for a mutant allele of the Pax6 gene, ... Cited by 297 - Related articles - BL Direct - All 4 versions
ME Hill, SL Asa, DJ Drucker - Molecular Endocrinology, 1999 - Endocrine Soc The primary function of islet A cells is the synthesis and secretion of
glucagon, an essential hormonal regulator of glucose homeostasis. The
proglucagon gene is also expressed in enteroendocrine L cells of the ... Cited by 51 - Related articles - BL Direct - All 5 versions
- ►iovs.org BK Chauhan, Y Yang, K Cveklova, A Cvekl - Investigative ophthalmology & visual science, 2004 - ARVO PURPOSE. Pax6 is essential for development of the eye, brain, and pancreas. Two
major products of PAX6 are specific DNA-binding proteins, PAX6 and PAX6(5a).
PAX6(5a) contains a short insertion influencing its DNA-binding activity. ... Cited by 21 - Related articles - BL Direct - All 5 versions
