L Piemonti, BE Leone, R Nano, A Saccani, P Monti, P … - Diabetes, 2002 - Am Diabetes Assoc We investigated the capacity of human islets to produce monocyte chemoattractant protein-1
(MCP-1). Primary cultures of pancreatic islets expressed and secreted MCP-1, as determined
by Northern blot, immunohistochemistry, in situ hybridization, and enzyme-linked ... Cited by 125 - Related articles - BL Direct - All 4 versions
MC Chen, P Proost, C Gysemans, C Mathieu, DL Eizirik - Diabetologia, 2001 - Springer Type I (insulin-dependent) diabetes mellitus is an au- toimmune disease characterized by the
selective de- struction of insulin-producing beta cells in the pan- creatic islets of Langerhans
[1]. This process is usually preceded by an inflammatory infiltration of mononu- clear cells, ... Cited by 99 - Related articles - BL Direct - All 5 versions
U Johansson, A Olsson, S Gabrielsson, B Nilsson, … - … and Biophysical Research …, 2003 - Elsevier Expression of immune modulating mediators in human Islets of Langerhans could have important
implications for development of autoimmunity in type 1 diabetes and influence the outcome of
clinical islet transplantation. Islets obtained from five donors were analyzed at various ... Cited by 67 - Related articles - All 5 versions
L Moberg, A Olsson, C Berne, M Felldin, A Foss, R … - Transplantation, 2003 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Cited by 53 - Related articles - BL Direct - All 6 versions
H Johansson, A Lukinius, L Moberg, T Lundgren, C … - Diabetes, 2005 - Am Diabetes Assoc There are strong indications that only a small fraction of grafts successfully engraft in clinical
islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction
(IBMIR) elicited by tissue factor, which is produced by the endocrine cells. In the present ... Cited by 80 - Related articles - All 6 versions
- ►thelancet.com L Moberg, H Johansson, A Lukinius, C Berne, A Foss, … - The Lancet, 2002 - Elsevier Intraportal transplantation of pancreatic islets offers improved glycaemic control and insulin independence
in type 1 diabetes mellitus, but intraportal thrombosis remains a possible complication. The thrombotic
reaction may explain why graft loss occurs and islets from more than one donor are ... Cited by 166 - Related articles - All 9 versions
- ►endojournals.org F Bertuzzi, S Marzorati, P Maffi, L Piemonti, R … - Journal of Clinical …, 2004 - Endocrine Soc Islet survival in the early posttransplantation period is likely to be influenced by inflammatory
events in and around islets. Twenty-seven human islet preparations were transplanted by 24
infusions into 14 patients with brittle type 1 diabetes under the Edmonton protocol. ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JL Contreras, C Eckstein, CA Smyth, MT Sellers, M … - Diabetes, 2003 - Am Diabetes Assoc Although ∼1 million islets exist in the adult human pancreas, current pancreas preservation
and islet isolation techniques recover <50%. Presently, cadaveric donors remain the sole source
of pancreatic tissue for transplantation. Brain death is characterized by activation of ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] W Bennet, B Sundberg, CG Groth, MD Brendel, D … - Diabetes, 1999 - Am Diabetes Assoc The remarkable difference in success rates between clinical pancreas transplantation and islet
transplanta- tion is poorly understood. Despite the same histocom- patibility barrier and similar
immunosuppressive treat- ments in both transplantation procedures, human intraportal ... Cited by 139 - Related articles - BL Direct - All 5 versions
B Kutlu, MI Darville, AK Cardozo, DL Eizirik - Diabetes, 2003 - Am Diabetes Assoc Pancreatic β-cells are selectively destroyed during the course of type 1 diabetes. In the early
stages of the disease, inflammatory infiltrates of mononuclear cells, containing predominantly
monocytes and T-cells, are present in the islets (insulitis). Chemokines, such as monocyte ... Cited by 56 - Related articles - BL Direct - All 5 versions
