K Eto, T Yamashita, Y Tsubamoto, Y Terauchi, K Hirose … - Diabetes, 2002 - Am Diabetes Assoc The role of phosphatidylinositol (PI) 3-kinase in the regulation of pancreatic ß-cell function was
investigated. PI 3-kinase activity in p85 regulatory subunit–deficient (p85 -/- ) islets was decreased
to 20% of that in wild-type controls. Insulin content and mass of rough endoplasmic ... Cited by 43 - Related articles - BL Direct - All 5 versions
[CITATION] Transgenic mice expressing a constitutively active Akt1/PKBα in pancreatic islet β- …
- ►endojournals.org WS Zawalich, KC Zawalich - Endocrinology, 2000 - Endocrine Soc Wortmannin (5–100 nM), a specific phosphatidyinositol 3-kinase inhibitor, augmented 8 mM
glucose-induced insulin secretion from control Sprague Dawley rat islets in a dose-dependent
manner. This effect persisted after its removal from the perifusion medium; however, this ... Cited by 35 - Related articles - BL Direct - All 3 versions
[CITATION] Tissue-specific knockouts of the insulin receptor tyrosine kinase
RN Kulkarni, MD Michael, CR Kahn - Genetic Manipulation of Receptor Expression and … Cited by 10 - Related articles
- ►endocrinology-journals.org [PDF] WS Zawalich, GJ Tesz, KC Zawalich - Journal of Endocrinology, 2002 - Soc Endocrinology We examined the effects of phosphatidylinositol 3-kinase (PI3K) inhibition by wortmannin or
LY294002 on glucose-induced secretion from mouse islets. Islets were collagenase isolated
and perifused or subjected to Western blot analyses and probed for insulin receptor- ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►nih.gov D Accili - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Pancreatic β cells synthesize, store, and secrete insulin in response to appropriate environmental
cues. The classic paradigm, as originally proposed by Matschinsky (1), holds that the products
of glucose metabolism in β cells control insulin production and release. In recent years, ... Cited by 58 - Related articles - BL Direct - All 6 versions
E Bertelli, M Regoli, D Orazioli, M Bendayan - Diabetologia, 2001 - Springer It is common to describe the endocrine and the exo- crine pancreas as if they were two distinct
and inde- pendent entities. However the pancreas is an inte- grated organ involved in the digestion
and absorption of nutrients on the one hand, and in the regulation of blood glucose ... Cited by 39 - Related articles - BL Direct - All 4 versions
JW Shaw, EO Latimer - American Journal of Physiology, 1926 - Am Physiological Soc Regeneration or extensive new growth of the pancreatic duct has been report,ed by Fisher
(1924b), and regeneration of pancreas tissue (acini and islets) from the pancreatic duct tissue
have been reported by several in- vestigators, Languesse and de la Roche (1902), Cecil ( ... Cited by 27 - Related articles
AM Lawrence, RA Prinz, E Paloyan, WA Kokal - Lancet, 1979 - ncbi.nlm.nih.gov 1: Lancet. 1979 Jun 23;1(8130):1354-5. Glucagon and insulin in pancreatic exocrine
secretions. Lawrence AM, Prinz RA, Paloyan E, Kokal WA. Publication Types: Letter.
Mesh Terms: Animals; Dogs; Glucagon/analysis*; Humans; ... Cited by 15 - Related articles
- ►nih.gov T Kitamura, Y Kido, S Nef, J Merenmies, LF … - Molecular and Cellular …, 2001 - Am Soc Microbiol Receptors of the insulin/insulinlike growth factor (IGF) family have been implicated in the regulation
of pancreatic -cell growth and insulin secretion. The insulin receptor-related receptor (IRR) is
an orphan receptor of the insulin receptor gene (Ir) subfamily. It is expressed at ... Cited by 55 - Related articles - BL Direct - All 3 versions
