- ►diabetesjournals.org ML McDaniel, CA Marshall, KL Pappan, G … - Diabetes, 2002 - Am Diabetes Assoc Mammalian target of rapamycin (mTOR) is a serine and threonine protein kinase
that regulates numerous cellular functions, in particular, the initiation of
protein translation. mTOR-mediated phosphorylation of both the ... Cited by 43 - Related articles - BL Direct - All 4 versions
ML McDaniel, CA Marshall, KL Pappan, G … - DIABETES, 2002 - Am Diabetes Assoc Mammalian target of rapamycin (mTOR) is a serine and threonine protein kinase
that regulates numerous cel- lular functions, in particular, the initiation of
protein translation. mTOR-mediated phosphorylation of both the ... Related articles
- ►diabetesjournals.org G Xu, G Kwon, WS Cruz, CA Marshall, ML … - Diabetes, 2001 - Am Diabetes Assoc Recent findings have demonstrated that the branched-chain amino acid leucine can
activate the translational regulators, phosphorylated heat- and acid-stable
protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70 s6k ), in an ... Cited by 85 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org I Briaud, MK Lingohr, LM Dickson, CE Wrede … - Diabetes, 2003 - Am Diabetes Assoc Glucose can activate the mitogen-activated kinases, Erk-1/2, and the
ribosomal-S6 kinase, p70 S6K , in β-cells, contributing to an increase in
mitogenesis. However, the signaling mechanism by which glucose induces ... Cited by 78 - Related articles - BL Direct - All 4 versions
I Briaud, LM Dickson, MK Lingohr, JF … - Journal of Biological Chemistry, 2005 - ASBMB Regulation of insulin receptor substrate (IRS)-2 expression is critical to
β-cell survival, but the mechanisms that control this are complex and
undefined. Here in pancreatic β-cells (INS-1), chronic exposure (>8 h) to ... Cited by 44 - Related articles - All 5 versions
- ►jbc.org G Xu, CA Marshall, TA Lin, G Kwon, RB … - Journal of Biological Chemistry, 1998 - ASBMB Although glucose regulates the biosynthesis of a variety of beta cell proteins
at the level of translation, the mechanism responsible for this effect is
unknown. We demonstrate that incubation of pancreatic islets with elevated ... Cited by 67 - Related articles - BL Direct - All 5 versions
Y Guiot, JC Henquin, J Rahier - European journal of pharmacology, 1994 - ncbi.nlm.nih.gov Whether hypoglycaemic sulphonylureas promote pancreatic beta-cell replication
(beta-cytotrophic action) remains controversial largely because previous studies
were based on semi-quantitative techniques only. Here, we used strict ... Cited by 15 - Related articles - All 2 versions
MK Lingohr, LM Dickson, CE Wrede, JF … - Molecular and cellular endocrinology, 2003 - Elsevier IRS-2 plays an important role in the control of pancreatic β-cell growth,
however it is unclear if other IRS family members are also involved. Using
recombinant adenoviruses, IRS-1, -2 and -3 expression was varied in the ... Cited by 19 - Related articles - All 5 versions
