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Troglitazone antagonizes metabolic effects of glucocorticoids in humans

- diabetesjournals.org
SM Willi, A Kennedy, P Wallace, E Ganaway, … - Diabetes, 2002 - Am Diabetes Assoc
Glucocorticoids induce insulin resistance in humans, whereas thiazolidinediones
enhance insulin sensitivity. Although the effects of glucocorticoids and
thiazolidinediones have been assessed in isolation, interaction between ...
Cited by 31 - Related articles - BL Direct - All 5 versions

Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetes


SM Willi, A Kennedy, BP Brant, P Wallace, … - Diabetes research and clinical practice, 2002 - Elsevier
We evaluated the efficacy of a thiazolidinedione in the treatment of diabetes
induced by glucocorticoids. We examined the effectiveness of troglitazone in
seven patients with long-standing steroid-induced diabetes. Five of the ...
Cited by 20 - Related articles - All 9 versions

[PDF] Troglitazone efficacy in a subject with glucocorticoid-induced diabetes.


K Fujibayashi, S Nagasaka, N Itabashi, A … - Diabetes care, 1999 - Am Diabetes Assoc
Type 2 diabetes is associated with inc reased oxidative stress, which may
contribute to microvascular and mac rovascular complications (1). One of the
consequences of increased oxidative st ress may be increased lipid pero xid ...
Cited by 10 - Related articles - BL Direct - All 5 versions

Peripheral insulin sensitivity is decreased by elevated non-esterified fatty acid level in …


O Mokuda, Y Sakamoto - Diabetes, nutrition & metabolism, 1999 - ncbi.nlm.nih.gov
The pathogenesis of glucocorticoid-induced insulin resistance in the peripheral
tissue was studied by perfusion experiments of the isolated rat hindquarter and
insulin tolerance tests in the rat with the cutting off operation of blood ...
Cited by 8 - Related articles - BL Direct - All 3 versions

Dexamethasone inhibits insulin-stimulated recruitment of GLUt4 to the cell surface in rat …


SP Weinstein, CM Wilson, A Pritsker, SW … - Metabolism, 1998 - Elsevier
To test the hypothesis that glucocorticoids reduce insulin-stimulated skeletal
muscle glucose transport by inhibiting the recruitment of GLUT4 glucose
transporters to the cell surface, we determined the effect of ...
Cited by 25 - Related articles - BL Direct - All 9 versions

[CITATION] Metabolism of CI-991: III. Distribution in rat tissues


K Kawai, Y Kawasaki, T Tokui, C Kuroiwa, E … - Food and Drug Administration, 1991
Cited by 2 - Related articles

[CITATION] Baseline and CRH-stimulated ACTH and cortisol levels after administration of the PPAR-g …


AB CannavoS, I Chiodini, T Vigo, A Russo, C … - Cushing's disease. Journal of Endocrinological …, 2004
Cited by 2 - Related articles

[CITATION] Biopharmaceutical studies on a new antidiabetic, CI-991, VIII. Pharmacokinetic study of dose …


T Izumi, E Maeda, K Sasahara, R Semmes, J … - Food and Drug Adminstration, 1992
Cited by 2 - Related articles

Risk of Unexplained Acute Liver Failure in Diabetes Mellitus--Reply


KA Chan, A Truman, JH Gurwitz, J Hurley, B … - Archives of Internal Medicine, 2003 - Am Med Assoc
Dr Graham claims that our study overestimated the rate of ALF and implies that
the sponsor had undue influence over the study design. The essence of ALF is
diminished hepatic function occurring over a period of a few months. 1 Our ...
Cited by 2 - Related articles - All 2 versions

[CITATION] Integrated summary of the safety of Troglitazone (CI-991)


B Baron, T Valiquett, A Vassos, T Venable - Food and Drug Administration, 1996
Cited by 2 - Related articles


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