- ►diabetesjournals.org GW Cline, K Johnson, W Regittnig, P Perret, E Tozzo, L … - Diabetes, 2002 - Am Diabetes Assoc Defects in liver and muscle glycogen synthesis are major factors contributing to postprandrial
hyperglycemia in patients with type 2 diabetes. Therefore, activation of glycogen synthase through
inhibition of glycogen synthase kinase (GSK)-3 represents a potential new therapeutic ... Cited by 101 - Related articles - BL Direct - All 4 versions
DB Ring, KW Johnson, EJ Henriksen, JM Nuss, D Goff, … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance plays a central role in the development of type 2 diabetes, but the precise defects
in insulin action remain to be elucidated. Glycogen synthase kinase 3 (GSK-3) can negatively
regulate several aspects of insulin signaling, and elevated levels of GSK-3 have been ... Cited by 104 - Related articles - BL Direct - All 4 versions
SE Nikoulina, TP Ciaraldi, S Mudaliar, L Carter, K … - Diabetes, 2002 - Am Diabetes Assoc Glycogen synthase kinase (GSK)-3 has been implicated in the regulation of multiple cellular
physiological processes in skeletal muscle. Selective cell-permeable reversible inhibitors
(INHs) of GSK-3 (CT98014 and CHIR98023 [Chiron, Emeryville, CA] and LiCl) were used ... Cited by 81 - Related articles - BL Direct - All 4 versions
- ►physiology.org EJ Henriksen, TR Kinnick, MK Teachey, … - American Journal of …, 2003 - Am Physiological Soc A role for elevated glycogen synthase kinase-3 (GSK-3) activity in the multifactorial etiology of
insulin resistance is now emerging. However, the utility of specific GSK-3 inhibition in modulating
insulin resistance of skeletal muscle glucose transport is not yet fully understood. ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org O Kaidanovich-Beilin, H Eldar-Finkelman - Journal of Pharmacology and …, 2006 - ASPET Glycogen synthase kinase-3 (GSK-3) is critically involved in insulin signaling, and its selective
inhibition may present a new therapy for treatment of insulin resistance and type 2 diabetes.
The current studies were designed to examine the impact of long-term in vivo inhibition of ... Cited by 31 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] H Eldar-Finkelman, SA Schreyer, MM Shinohara, RC … - Diabetes, 1999 - Am Diabetes Assoc Although the precise mechanisms contributing to insu- lin resistance and type 2 diabetes are
unknown, it is believed that defects in downstream components of the insulin signaling pathway
may be involved. In this work, we hypothesize that a serine/threonine kinase, glycogen ... Cited by 108 - Related articles - BL Direct - All 5 versions
NJ Pearce, JRS Arch, JC Clapham, MP Coghlan, SL … - Metabolism, 2004 - Elsevier Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in skeletal muscle
in type 2 diabetes, and inversely correlated with both glycogen synthase activity and insulin-stimulated
glucose disposal. To explore this relationship, we have produced transgenic mice that ... Cited by 39 - Related articles - All 4 versions
- ►aspetjournals.org B Plotkin, O Kaidanovich, I Talior, H Eldar- … - Journal of Pharmacology …, 2003 - ASPET Glycogen synthase kinase-3 (GSK-3) was shown to be a key factor in attenuation of the cellular
action of insulin. We speculated that inhibition of GSK-3 might have a potential therapeutic value
in treatment of insulin resistance and type 2 diabetes. Here, we present a novel class of ... Cited by 63 - Related articles - BL Direct - All 4 versions
PA Lochhead, M Coghlan, SQ Rice, C Sutherland - Diabetes, 2001 - ncbi.nlm.nih.gov A major action of insulin is to regulate the transcription rate of specific genes. The expression
of these genes is dramatically altered in type 2 diabetes. For example, the expression of two
hepatic genes, glucose-6-phosphatase and PEPCK, is normally inhibited by insulin, but ... Cited by 86 - Related articles
- ►diabetesjournals.org [PDF] SE Nikoulina, TP Ciaraldi, S Mudaliar, P Mohideen, L … - Diabetes, 2000 - Am Diabetes Assoc Glycogen synthase (GS) activity is reduced in skeletal muscle of type 2 diabetes, despite normal
protein expression, consistent with altered GS regulation. Glycogen synthase kinase-3
(GSK-3) is involved in reg- ulation (phosphorylation and deactivation) of GS. To access ... Cited by 156 - Related articles - BL Direct - All 5 versions
