DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy
production. Because the insulin resistance of skeletal muscle in type 2 diabetes
and obesity entails dysregulation of the oxidation of both carbohydrate and ... Cited by 531 - Related articles - BL Direct - All 4 versions
- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England journal of medicine, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination
with infusions of [6,6- 2 H 2 ]glucose in healthy, young, lean,
insulin-resistant offspring of patients with type 2 diabetes and insulin- ... Cited by 781 - Related articles - BL Direct - All 14 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 663 - Related articles - BL Direct - All 15 versions
- ►shouxi.net VB Ritov, EV Menshikova, J He, RE Ferrell, … - Diabetes, 2005 - Am Diabetes Assoc The current study addresses a novel hypothesis of subcellular distribution of
mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus
lateralis muscle was obtained by percutaneous biopsy from 11 volunteers ... Cited by 194 - Related articles - All 6 versions
- ►upmc.fr [PDF] KF Petersen, D Befroy, S Dufour, J Dziura, C … - Science, 2003 - sciencemag.org 420 article(s) on the ISI Web of Science. cited by This article has been ... :
subject collections This article appears in the following ... 2003 by the
American Association for the Advancement of Science; all rights reserved. ... Cited by 695 - Related articles - All 14 versions
VK Mootha, CM Lindgren, KF Eriksson, A … - Nature genetics, 2003 - ws1.izbi.uni-leipzig.de Type 2 diabetes mellitus (DM2) affects over 110 million people world- wide and
is a principal contributor to atherosclerotic vascular disease, blindness,
amputation and kidney failure 1 . Defects in insulin secretion are observed ... Cited by 1289 - Related articles - BL Direct - All 24 versions
- ►physiology.org JA Simoneau, DE Kelley - Journal of Applied Physiology, 1997 - Am Physiological Soc A GOOD DEAL OF THE FUNCTIONAL DIVERSITY of skeletal muscle derives from
differences of fiber type distribution, and this also helps determine metabolic
diversity of skeletal muscle. Insulin-stimulated metabolism in skeletal ... Cited by 171 - Related articles - BL Direct - All 5 versions
- ►fasebj.org JA SIMONEAU, J VEERKAMP… - The FASEB Journal, 1999 - FASEB A number of biochemical defects have been identified in glucose metabolism
within skeletal muscle in obesity, and positive effects of weight loss on
insulin resistance are also well established. Less is known about the ... Cited by 217 - Related articles - BL Direct - All 5 versions
- ►nih.gov K Morino, KF Petersen, S Dufour, D Befroy, J … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig To further explore the nature of the mitochondrial dysfunction and insulin
resistance that occur in the muscle of young, lean, normoglycemic,
insulin-resistant offspring of parents with type 2 diabetes (IR offspring), ... Cited by 165 - Related articles - BL Direct - All 10 versions
J He, S Watkins, DE Kelley - Diabetes, 2001 - Am Diabetes Assoc In obesity and type 2 diabetes, skeletal muscle has been observed to have a
reduced oxidative enzyme activity, increased glycolytic activity, and increased
lipid content. These metabolic characteristics are related to insulin ... Cited by 170 - Related articles - BL Direct - All 4 versions
