JA Houmard, CJ Tanner, C Yu, PG Cunningham, WJ … - Diabetes, 2002 - Am Diabetes Assoc Increases in intramyocellular long-chain fatty acyl-CoAs (LCACoA) have been implicated in the
pathogenesis of insulin resistance in skeletal muscle. To test this hypothesis, we measured muscle
(vastus lateralis) LCACoA content and insulin action in morbidly obese patients (n = 11) ... Cited by 74 - Related articles - BL Direct - All 5 versions
GJ Cooney, AL Thompson, SM Furler, J … - ANNALS-NEW …, 2002 - interscience.wiley.com Abstract: A common observation in animal models and in humans is that accumulation of muscle
triglyceride is associated with the development of insulin resistance. In animals, this is true of
genetic models of obesity and nutritional models of insulin resistance generated by ... Cited by 80 - Related articles - BL Direct - All 4 versions
- ►physiology.org RE Gray, CJ Tanner, WJ Pories, KG … - American Journal of …, 2003 - Am Physiological Soc The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular
lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained
from morbidly obese individuals [body mass index (BMI) 52.2 ± 2.5 kg/m 2 ; n = 6] before ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►physiology.org BA Ellis, A Poynten, AJ Lowy, SM Furler, … - American Journal of …, 2000 - Am Physiological Soc Long-chain acyl-CoAs (LCACoA) are an activated lipid species that are key metabolites in lipid
metabolism; they also have a role in the regulation of other cellular processes. However, few
studies have linked LCACoA content in rat and human muscle to changes in nutritional ... Cited by 150 - Related articles - BL Direct - All 4 versions
- ►physiology.org MW Hulver, JR Berggren, RN Cortright, … - American Journal of …, 2003 - Am Physiological Soc The objectives of this study were to 1) examine skeletal muscle fatty acid oxidation in individuals
with varying degrees of adiposity and 2) determine the relationship between skeletal muscle
fatty acid oxidation and the accumulation of long-chain fatty acyl-CoAs. Muscle was ... Cited by 105 - Related articles - BL Direct - All 6 versions
- ►physiology.org JP Thyfault, RM Kraus, RC Hickner, AW … - American Journal of …, 2004 - Am Physiological Soc Skeletal muscle from extremely obese individuals exhibits decreased lipid oxidation compared
with muscle from lean controls. It is unknown whether this effect is observed in vivo or whether
the phenotype is preserved after massive weight loss. The objective of this study was to ... Cited by 26 - Related articles - BL Direct - All 4 versions
C Pender, ID Goldfine, CJ Tanner, WJ Pories, KG … - International Journal of …, 2004 - nature.com OBJECTIVE: Obesity results in insulin resistance. Bariatric surgery for obese individuals induces
weight loss, improves insulin sensitivity, and lowers insulin levels. We investigated the mechanisms
of this improvement. ... DESIGN: Insulin receptor (IR) content, IR signaling, and ... Cited by 35 - Related articles - BL Direct - All 4 versions
BH Goodpaster, R Theriault, SC Watkins, DE Kelley - Metabolism, 2000 - Elsevier The triglyceride content of skeletal muscle samples determined by lipid extraction correlates
with the severity of insulin-resistant glucose metabolism in muscle. To determine whether this
reflects increased triglyceride within muscle fibers and to test the-hypothesis that the lipid ... Cited by 158 - Related articles - BL Direct - All 3 versions
SM Furler, AM Poynten, AD Kriketos, AJ Lowy, BA Ellis, … - Obesity, 2001 - nature.com Discussion: The mechanisms by which altered lipid metabolism in skeletal muscle influences
insulin action may not be related directly to those linking central fat and insulin sensitivity. In
particular, it is unlikely that muscle accumulation of lipids directly derived from labile ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►endojournals.org CR Bruce, MJ Anderson, AL Carey, DG … - Journal of Clinical …, 2003 - Endocrine Soc We determined whole-body insulin sensitivity, long-chain fatty acyl coenzyme A (LCACoA)
content, skeletal muscle triglyceride (TG m ) concentration, fatty acid transporter protein
content, and oxidative enzyme activity in eight patients with type 2 diabetes (TYPE 2); six ... Cited by 80 - Related articles - BL Direct - All 6 versions
