- ►diabetesjournals.org A Cebrian, A García-Ocaña, KK Takane, D … - Diabetes, 2002 - Am Diabetes Assoc Pancreatic β-cell survival is critical in the setting of diabetes as well as in
islet transplantation. Transgenic mice overexpressing parathyroid
hormone-related protein (PTHrP) targeted to β-cells using the rat insulin ... Cited by 37 - Related articles - BL Direct - All 4 versions
A García-Ocaña, RC Vasavada, A Cebrian, V … - Diabetes, 2001 - Am Diabetes Assoc Recent advances in human islet transplantation have highlighted the need for
expanding the pool of ß-cells available for transplantation. We have developed
three transgenic models in which growth factors (hepatocyte growth factor ... Cited by 80 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org [PDF] S Gahr, M Merger, LC Bollheimer, CG … - Journal of molecular endocrinology, 2002 - Soc Endocrinology We investigated the role of hepatocyte growth factor (HGF) in β-cell growth and
its complex intracellular signal transduction pathways. Cell proliferation was
measured in the β-cell line INS-1 using [3H]thymidine incorporation. ... Cited by 35 - Related articles - BL Direct - All 8 versions
- ►endojournals.org SE Porter, RL Sorenson, P Dann, A Garcia- … - Endocrinology, 1998 - Endocrine Soc PTH-related protein (PTHrP) is a paracrine/autocrine factor produced in most
cell types in the body. Its functions include the regulation of cell cycle, of
differentiation, of apoptosis, and of developmental events. One of the ... Cited by 43 - Related articles - BL Direct - All 4 versions
Y Fujinaka, D Sipula, A Garcia-Ocaña, RC … - Diabetes, 2004 - Am Diabetes Assoc Transgenic overexpression of either parathyroid hormone-related peptide (PTHrP)
or mouse placental lactogen type 1 (mPL1) in pancreatic β-cells, using the rat
insulin II promoter (RIP), results in islet hyperplasia either through ... Cited by 27 - Related articles - BL Direct - All 5 versions
- ►jbc.org RC Vasavada, C Cavaliere, AJ D'Ercole, P … - Journal of Biological Chemistry, 1996 - ASBMB Parathyroid hormone-related protein (PTHrP) is produced by the pancreatic islet.
It also has receptors on islet cells, suggesting that it may serve a paracrine
or autocrine role within the islet. We have developed transgenic mice, ... Cited by 85 - Related articles - BL Direct - All 4 versions
- ►jbc.org RC Vasavada, A Garcia-Ocana, WS Zawalich, … - Journal of Biological Chemistry, 2000 - ASBMB The factors that regulate pancreatic beta cell proliferation are not well
defined. In order to explore the role of murine placental lactogen (PL)-I
(mPL-I) in islet mass regulation in vivo, we developed transgenic mice in ... Cited by 86 - Related articles - BL Direct - All 4 versions
- ►jbc.org A Garcia-Ocana, KK Takane, VT Reddy, JC … - Journal of Biological Chemistry, 2003 - ASBMB Hepatocyte growth factor (HGF) increases beta cell proliferation and function in
rat insulin promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also
function superiorly to normal islets in a transplant setting. Here, we ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] ML Villanueva-Penacarrillo, J Cancelas, F de … - Journal of Endocrinology, 1999 - Soc Endocrinology Parathyroid hormone (PTH)-related protein (PTHrP) is present in the pancreatic
islet. Recent data in transgenic mice suggest that PTHrP might modulate islet
mass and insulin secretion. In the present study, we assessed the effect of ... Cited by 16 - Related articles - All 6 versions
- ►jbc.org A Garcia-Ocana, KK Takane, MA Syed, WM … - Journal of Biological Chemistry, 2000 - ASBMB Hepatocyte growth factor (HGF) is produced in pancreatic mesenchyme-derived
cells and in islet cells. In vitro, HGF increases the insulin content and
proliferation of islets. To study the role of HGF in the islet in vivo, we ... Cited by 135 - Related articles - BL Direct - All 4 versions
