- ►diabetesjournals.org A Flyvbjerg, F Dagnæs-Hansen, AS De Vriese, BF … - Diabetes, 2002 - Am Diabetes Assoc Diabetic nephropathy in type 2 diabetic patients is a frequent complication associated with increased
morbidity and mortality. Various growth factors and cytokines have been implicated in the pathogenesis
of diabetic kidney disease, including vascular endothelial growth factor (VEGF). To ... Cited by 180 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org ANS VRIESE, RG TILTON, M ELGER, CC … - Journal of the American …, 2001 - Am Soc Nephrol Abstract. Vascular endothelial growth factor (VEGF) is a cytokine that potently stimulates
angiogenesis, microvascular hyperpermeability, and endothelium-dependent vasodilation, effects
that are largely mediated by endothelial nitric oxide synthase (eNOS). The expression of ... Cited by 282 - Related articles - BL Direct - All 4 versions
ME Cooper, D Vranes, S Youssef, SA … - DIABETES-NEW …, 1999 - Am Diabetes Assoc It has been suggested that the cytokine vascular endothelial growth factor (VEGF) has an important
role in the pathogenesis of diabetic retinopathy, but its role in nephropathy has not been clearly
demonstrated. Assessment of VEGF, 1 2 5 I-VEGF binding, and vascular endothelial ... Cited by 254 - Related articles - BL Direct - All 4 versions
D Senthil, GG Choudhury, C Mclaurin, BS Kasinath - Kidney international, 2003 - nature.com Kidney International aims to inform the renal researcher and practicing nephrologists on all
aspects of renal research. Clinical and basic renal research, commentaries, The Renal Consult,
Nephrology sans Frontieres, minireviews, reviews, Nephrology Images, Journal Club. Published ... Cited by 59 - Related articles - BL Direct - All 4 versions
K Tsuchida, Z Makita, S Yamagishi, T Atsumi, H … - Diabetologia, 1999 - Springer The dominant histological feature of diabetic nephro- pathy is expansion of the extracellular matrix
(ECM) in the mesangial areas of the glomeruli and thicken- ... Suppression of transforming growth
factor beta and vascular ... K. Tsuchida 1 , Z. Makita 1 , S. Yamagishi 2 , T. Atsumi 1 , H. ... Cited by 154 - Related articles - BL Direct - All 3 versions
Y Kanesaki, D Suzuki, G Uehara, M Toyoda, T … - American Journal of …, 2005 - Elsevier Background: In diabetic nephropathy (DN) small vessels are frequently observed around the
glomerular vascular pole in addition to normal afferent and efferent arterioles; this is regarded
as neovascularization. Because vascular endothelial growth factor (VEGF) promotes ... Cited by 35 - Related articles - All 8 versions
DR Cha, NH Kim, JW Yoon, SK Jo, WY Cho, HK Kim, … - Kidney International, 2000 - nature.com A high ambient glucose concentration in the culture medium increased VEGF mRNA expression
and protein production within 3 h in a concentration-dependent manner. A protein kinase C
(PKC) inhibitor and PKC down-regulation inhibited glucose-induced increases in VEGF ... Cited by 119 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Chen, Y Kasama, JS Lee, B Jim, M Marin, FN … - Diabetes, 2004 - Am Diabetes Assoc Podocyte-derived vascular endothelial growth factor (VEGF) is upregulated in diabetes and may
contribute to albuminuria. Although believed to act upon the glomerular endothelium, VEGF may
have pronounced effects on the podocyte itself. The functionality of this VEGF autocrine ... Cited by 51 - Related articles - BL Direct - All 4 versions
MC Iglesias-de la Cruz, FN Ziyadeh, M Isono, M … - Kidney international, 2002 - nature.com The podocyte takes center stage in the pathogenesis of glomerular basement membrane
(GBM) thickening and proteinuria in diabetic glomerulopathy. In part, GBM thickening may occur
when the podocyte synthesizes increased amounts of collagen IV. Proteinuria may ... Cited by 121 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org J Menne, JK Park, M Boehne, M Elger, C Lindschau, T … - Diabetes, 2004 - Am Diabetes Assoc Activation of protein kinase C (PKC) isoforms has been implicated in the pathogenesis of diabetic
nephropathy. We showed earlier that PKC-α is activated in the kidneys of hyperglycemic
animals. We now used PKC-α −/− mice to test the hypothesis that this PKC isoform ... Cited by 52 - Related articles - BL Direct - All 4 versions
