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Scholar Results 1 - 10 of about 101 related to Chandra: Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. (0.11 sec) 

Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes


D Chandra, EB Jackson, KV Ramana, R Kelley … - Diabetes, 2002 - Am Diabetes Assoc
Increased glucose utilization by aldose reductase (AR) has been implicated in
the development of diabetes complications. However, the mechanisms that regulate
AR during diabetes remain unknown. Herein we report that several nitric ...
Cited by 47 - Related articles - BL Direct - All 6 versions

Metabolic regulation of aldose reductase activity by nitric oxide donors


BL Dixit, KV Ramana, D Chandra, EB Jackson, … - Chemico-Biological Interactions, 2001 - Elsevier
Regulation of aldose reductase (AR), a member of the aldo–keto reductase
superfamily, by nitric oxide (NO) donors was examined. Incubation of human
recombinant AR with S-nitrosoglutathione (GSNO) led to inactivation of the ...
Cited by 5 - Related articles - All 2 versions

Active site modification of aldose reductase by nitric oxide donors


A Chandra, S Srivastava, JM Petrash, A … - Biochimica et Biophysica Acta (BBA)/Protein …, 1997 - Elsevier
ELSEVIER BIOCHIMICA ET BIOPHYSICA ACTA ВВЦ Biochimica et Biophysica Acta 1341
(1997) 217-222 Active site modification of aldose reductase by nitric oxide
donors Animesh Chandra a, Sanjay Srivastava a, J. Mark Petrash c, Aruni ...
Cited by 29 - Related articles - All 4 versions

Human placental aldose reductase: role of Cys-298 in substrate and inhibitor binding


A Bhatnagar, SQ Liu, N Ueno, B Chakrabarti, … - Biochimica et Biophysica Acta (BBA)-Protein …, 1994 - Elsevier
Steady-state kinetic and inhibition properties of human placental aldose
reductase carboxymethylated at Cys-298 were investigated. A comparison of the
primary deuterium kinetic isotope effect on the reduced and the ...
Cited by 15 - Related articles - All 4 versions

[CITATION] Aldose reductase: congenital and injurious profiles of an enigmatic enzyme


A Bhatnagar, SK Srivastava - Biochemical medicine and metabolic biology, 1992 - cat.inist.fr
Aldose reductase: congenital and injurious profiles of an enigmatic enzyme.
A BHATNAGAR, SK SRIVASTAVA Biochemical medicine and metabolic ...
Cited by 65 - Related articles - BL Direct - All 2 versions

Regulation of aldose reductase and the polyol pathway activity by nitric oxide


SK Srivastava, KV Ramana, D Chandra, S … - Chemico-biological interactions, 2003 - Elsevier
Increased flux of glucose through the polyol pathway has been implicated in the
pathophysiology of secondary diabetic complications. The first step of this
pathway, which generates sorbitol from glucose, is catalyzed by aldose ...
Cited by 20 - Related articles - All 3 versions

Structural and kinetic modifications of aldose reductase by S-nitrosothiols.

- nih.gov [PDF] 
S Srivastava, BL Dixit, KV Ramana, A Chandra … - Biochemical Journal, 2001 - pubmedcentral.nih.gov
Modification of aldose reductase (AR) by the nitrosothiols S-nitroso-N-acetyl
penicillamine (SNAP) and N-(β-gluco- pyranosyl)-N#-acetyl-S-
nitrosopenicillamide (glyco-SNAP) re- sulted in a 3–7-fold increase in ...
Cited by 22 - Related articles - BL Direct - All 10 versions

Involvement of aldose reductase in vascular smooth muscle cell growth and lesion formation …

- ahajournals.org
J Ruef, SQ Liu, C Bode, M Tocchi, S … - Arteriosclerosis, thrombosis, and vascular biology, 2000 - Am Heart Assoc
Abstract—Abnormal proliferation of vascular smooth muscle cells (VSMCs) is an
important feature of atherosclerosis, restenosis, and hypertension. Although
multiple mediators of VSMC growth have been identified, few effective ...
Cited by 65 - Related articles - BL Direct - All 6 versions

Aldose reductase-catalyzed reduction of aldehyde phospholipids


S Srivastava, M Spite, JO Trent, MB West, Y … - Journal of Biological Chemistry, 2004 - ASBMB
Oxidation of unsaturated phospholipids results in the generation of aldehyde
side chains that remain esterified to the phospholipid backbone. Such "core"
aldehydes elicit immune responses and promote inflammation. However, the ...
Cited by 37 - Related articles - All 5 versions

Direct measurement of polyol pathway activity in the ocular lens.


RG Gonzalez, P Barnett, J Aguayo, HM Cheng … - Diabetes, 1984 - Am Diabetes Assoc
A method to measure the polyol pathway metabolic flux in the intact rabbit lens
by 13C nuclear magnetic resonance spectroscopy is described. In the lens exposed
to 35.5 mM glucose, the polyol pathway accounts for 1/3 of the total ...
Cited by 72 - Related articles - All 4 versions


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