- ►diabetesjournals.org HC Chen, SJ Stone, P Zhou, KK Buhman, RV … - Diabetes, 2002 - Am Diabetes Assoc Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two DGAT
enzymes known to catalyze the final step in mammalian triglyceride synthesis.
Mice deficient in DGAT1 are resistant to obesity and have enhanced insulin ... Cited by 52 - Related articles - BL Direct - All 7 versions
- ►nih.gov HC Chen, DR Jensen, HM Myers, RH Eckel, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Recent studies have identified the white adipose tissue (WAT) as an important
endocrine organ that regulates energy and glucose metabolism via a number of
secreted factors. Mice lacking acyl CoA:diacylglycerol acyltransferase 1 ... Cited by 57 - Related articles - BL Direct - All 9 versions
- ►nih.gov HC Chen, SJ Smith, Z Ladha, DR Jensen, LD … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two known
DGAT enzymes that catalyze the final step in mammalian triglyceride synthesis.
DGAT1-deficient mice are resistant to diet-induced obesity through a ... Cited by 130 - Related articles - BL Direct - All 8 versions
- ►physiology.org HC Chen, Z Ladha, SJ Smith, RV Farese Jr - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc Mice lacking acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme in
triglyceride synthesis, have increased energy expenditure and therefore are
resistant to obesity. Because ambient temperature can significantly affect ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Chen, L Liu, Y Zhang, HN Ginsberg, YH Yu - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance is often associated with obesity. We tested whether
augmentation of triglyceride synthesis in adipose tissue by transgenic
overexpression of the diacylglycerol aclytransferase-1 (Dgat1) gene causes ... Cited by 21 - Related articles - BL Direct - All 5 versions
HC Chen… - Trends in Cardiovascular Medicine, 2000 - Elsevier Because triglycerides are considered essential for survival and their synthesis
has been thought to occur through a single mechanism, inhibiting triglyceride
synthesis has been largely unexplored as a possible target for obesity ... Cited by 36 - Related articles - All 4 versions
- ►jbc.org YH Yu, Y Zhang, P Oelkers, SL Sturley, DJ … - Journal of Biological Chemistry, 2002 - ASBMB Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) catalyzes the final step of
triglyceride synthesis in mammalian cells. Data obtained from DGAT1-knockout
mice have indicated that this enzyme plays an important role in energy ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org HC Chen, M Rao, MP Sajan, M Standaert, Y … - Diabetes, 2004 - Am Diabetes Assoc Mice that lack acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme
in mammalian triglyceride synthesis, have decreased adiposity and increased
insulin sensitivity. Here we show that insulin-stimulated glucose transport ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org HC Chen, RV Farese Jr - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc Because the ability to make triglycerides is essential for the accumulation of
adipose tissue, inhibition of triglyceride synthesis may ameliorate obesity and
its related medical consequences. Acyl coenzyme A (CoA):diacylglycerol ... Cited by 44 - Related articles - All 6 versions
EH Ludwig, RW Mahley, E Palaoglu, S … - Clinical genetics, 2002 - interscience.wiley.com Triglyceride synthesis is catalyzed by acyl CoA:diacylglycerol acyltransferases
(DGAT), microsomal enzymes that use diacylglycerol and fatty acyl CoAs as
substrates. Because DGAT1 expression is up-regulated during adipocyte ... Cited by 36 - Related articles - BL Direct - All 4 versions
